Long-term modulation of electrical synapses in the mammalian thalamus
Long-term modulation of electrical synapses in the mammalian thalamus
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DOI：
10.1126/science.1114655
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发表时间：
2005-12-16
期刊：
影响因子：
56.9
通讯作者：
Connors, BW
中科院分区：
文献类型：
--
作者：
Landisman, CE;Connors, BW
电突触在哺乳动物丘脑和新皮层中的抑制性神经元之间是常见的。突触调制，允许神经元之间的通信的灵活性，已被广泛研究的化学突触，但调制的电突触在哺乳动物的大脑几乎没有被检查。我们发现，代谢型谷氨酸受体的激活，通过内源性神经递质或激动剂，导致长期减少大鼠丘脑网状核的抑制性神经元之间的电突触强度。
Electrical synapses are common between inhibitory neurons in the mammalian thalamus and neocortex. Synaptic modulation, which allows flexibility of communication between neurons, has been studied extensively at chemical synapses, but modulation of electrical synapses in the mammalian brain has barely been examined. We found that the activation of metabotropic glutamate receptors, via endogenous neurotransmitter or by agonist, causes long-term reduction of electrical synapse strength between the inhibitory neurons of the rat thalamic reticular nucleus.