Epidemiological analysis of tongue cancer in South Australia for the 24-year period, 1977-2001
Epidemiological analysis of tongue cancer in South Australia for the 24-year period, 1977-2001
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DOI：
10.1111/j.1834-7819.2006.tb00395.x
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发表时间：
2006-03-01
影响因子：
2.1
通讯作者：
Luke, C
中科院分区：
文献类型：
--
作者：
Lam, L;Logan, RM;Luke, C
背景：舌癌（141 ICD-9）是西方国家最常见的口腔内恶性肿瘤。近几十年来，欧洲和美国的舌癌发病率和死亡率都有所增加，而生存率却没有提高。本研究的目的是确定1977 - 2001年24年间南澳舌癌的流行病学和生存趋势。方法：南澳卫生部流行病学分支中央癌症登记处提供的以人群为基础的舌癌数据。计算男性和女性的标准化发病率和死亡率。根据时间段、年龄、性别和舌亚部位进行Kaplan-Meier生存分析。考克斯回归分析，以确定影响生存的因素。结果：在这24年期间，611例舌癌（男性398例，女性213例），其中大多数是鳞状细胞癌。最常见的诊断年龄为男性65-69岁，女性60-64岁。50例（占所有舌癌病例的8.18%）发生在40岁或40岁以下的患者中。报告的最常见的癌症亚部位是“未指明部位”（48.45%）、舌根（18.49%）和舌根侧缘（25.53%）。南澳男性和女性的年龄标准化发病率和死亡率相对较低且稳定，在此期间舌癌的生存率没有显著改善。生存率的显着预测因素是性别，年龄和舌子网站，与男性，高龄和舌根与较差survival.Conclusions：舌癌是一个重要的健康问题与生存不良。早期发现和诊断是重要的，以提高这种恶性肿瘤的生存率。
Background: Tongue cancer (141 ICD-9) is the most common intra-oral malignancy in Western countries. In recent decades, reported tongue cancer incidence and mortality rates have increased both in Europe and in the United States, whilst survival has not improved. This study aimed to determine the epidemiology and survival trends of tongue cancer in South Australia over the 24-year period from 1977 to 2001.Methods: Population-based data for tongue cancer were provided by the Central Cancer Registry Unit of the Epidemiology Branch of the South Australian Department of Health. Age-standardized incidence and mortality rates for males and females were calculated. Kaplan-Meier survival analysis was conducted according to time periods, age, sex and tongue sub-sites. Cox regression analysis was used to determine factors that influenced survival.Results: During this 24-year period, 611 cases of tongue cancer (398 males, 213 females) were reported, the majority of which were squamous cell carcinomas. The most common age of diagnosis was 65-69 years in males and 60-64 years in females. Fifty cases (8.18 per cent of all tongue cancer cases) occurred in patients 40 years or younger. The most common cancer sub-sites reported were 'unspecified site' (48.45 per cent), lateral border (25.53 per cent) and base (18.49 per cent) of the tongue. The age-standardized incidence and mortality rates for males and females in South Australia were relatively low and stable, and there was no significant improvement in survival of tongue cancer over this period. Significant predictors for survival were sex, age and tongue sub-sites, with male, advanced age and base of tongue associated with poorer survival.Conclusions: Tongue cancer is an important health issue associated with poor survival. Early detection and diagnosis is important in order to improve survival rate for this malignancy.