High fat diet enhances cardiac abnormalities in SHR rats: Protective role of heme oxygenase-adiponectin axis.
High fat diet enhances cardiac abnormalities in SHR rats: Protective role of heme oxygenase-adiponectin axis.
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DOI：
10.1186/1758-5996-3-37
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发表时间：
2011-12-23
影响因子：
4.8
通讯作者：
Abraham NG
中科院分区：
文献类型：
--
作者：
Cao J;Sodhi K;Puri N;Monu SR;Rezzani R;Abraham NG
高膳食脂肪摄入是心血管和代谢功能障碍包括肥胖症、心肌病和高血压发展的主要危险因素。本研究旨在研究高脂饮食对自发性高血压大鼠（SHR）心血管结构和功能的影响，高脂饮食喂养15周，旨在模拟代谢综合征的表型。使用包括体重、总胆固醇和血压水平在内的参数证实代谢综合征样表型的发展。与对照组相比，高脂饮食损害了乙酰胆碱引起的血管舒张，并加重了SHR的心功能障碍，表现为左心室功能降低和冠状动脉阻力（CR）升高（p < 0.05）。组织学检查显示HF饮食的SHR心脏中存在显著的心肌和血管周围纤维化。这种心功能不全与高脂饲料喂养的SHR中炎性细胞因子、考克斯-2、NOX-2、TxB 2表达水平的增加以及超氧化物（O2-）水平的增加有关（p < 0.05）。在HF喂养的大鼠中，通过钴原卟啉（CoPP，3 mg/kg）诱导HO-1不仅改善心脏性能参数，而且防止心肌和血管周围纤维化。CoPP的这些作用伴随着心脏脂联素水平、pAMPK、peNOS和iNOS表达水平的增加;在HF喂养的SHR中，其他方面显著减弱（p < 0.05）。通过同时给予HO抑制剂锡中卟啉（SnMP）来预防CoPP的这种有益作用证实了HO系统在介导这种作用中的作用。总之，这项新的研究表明，HO-1的上调通过钝化氧化应激、考克斯-2水平和增加HF饮食的高血压大鼠的脂联素水平来改善心脏和血管功能障碍。
High dietary fat intake is a major risk factor for development of cardiovascular and metabolic dysfunction including obesity, cardiomyopathy and hypertension. The present study was designed to examine effect of high fat (HF) diet on cardio-vascular structure and function in spontaneously hypertensive rats (SHR), fed HF diet for 15 weeks, a phenotype designed to mimic metabolic syndrome. Development of metabolic syndrome like phenotype was confirmed using parameters, including body weight, total cholesterol and blood pressure levels. High fat diet impaired vascular relaxation by acetylcholine and exacerbated cardiac dysfunction in SHRs as evidenced by lower left ventricular function, and higher coronary resistance (CR) as compared to controls (p < 0.05). The histological examination revealed significant myocardial and peri-vascular fibrosis in hearts from SHRs on HF diet. This cardiac dysfunction was associated with increased levels of inflammatory cytokines, COX-2, NOX-2, TxB2 expression and increase in superoxide (O2-) levels in SHR fed a HF diet (p < 0.05). HO-1 induction via cobalt-protoporphyrin (CoPP,3 mg/kg), in HF fed rats, not only improved cardiac performance parameters, but also prevented myocardial and perivascular fibrosis. These effects of CoPP were accompanied by enhanced levels of cardiac adiponectin levels, pAMPK, peNOS and iNOS expression; otherwise significantly attenuated (p < 0.05) in HF fed SHRs. Prevention of such beneficial effects of CoPP by the concurrent administration of the HO inhibitor stannic mesoporphyrin (SnMP) corroborates the role of HO system in mediating such effects. In conclusion, this novel study demonstrates that up-regulation of HO-1 improves cardiac and vascular dysfunction by blunting oxidative stress, COX-2 levels and increasing adiponectin levels in hypertensive rats on HF diet.
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影响因子：
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作者：
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DOI：
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发表时间：
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期刊：
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影响因子：
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