Inter-tissue expression patterns of the key metabolic biomarker PGC-1α in severely obese individuals: Implication in obesity-induced disease
Inter-tissue expression patterns of the key metabolic biomarker PGC-1α in severely obese individuals: Implication in obesity-induced disease
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DOI：
10.1016/j.hjc.2018.08.002
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发表时间：
2019-09-01
影响因子：
4.1
通讯作者：
Sotiropoulou-Bonikou, Georgia
中科院分区：
文献类型：
--
作者：
Balampanis, Konstantinos;Chasapi, Athina;Sotiropoulou-Bonikou, Georgia
目的：PGC-1 α是线粒体生物合成、氧化磷酸化和脂肪酸代谢的重要调节因子。我们的研究重点是PGC 1 α在病态肥胖中的作用，在五个不同的组织，收集从50例严重肥胖患者在计划减肥surgery.Methods：调查的组织包括皮下脂肪组织（SAT），内脏脂肪组织（VAT），骨骼肌（SM），肌外脂肪组织（EMAT）和肝脏。PGC 1 α的表达进行了研究，免疫组化和评价与microscopic.Results：我们的研究结果突出了几个组织对（VAT-SAT，VAT-SM，VAT-EMAT，SAT-SM，SAT-EMAT，SM-EMAT）之间的PGC-1 α的表达显着的正相关性。此外，我们发现PGC 1 α在VAT与CD 68表达在骨骼肌和EMAT之间的显着负相关性，这意味着可能的保护作用，PGC 1 α对肥胖引起的inflammation.Conclusion：揭开组织间通信网络PGC-1 α的表达在病态肥胖，将使更多的了解其在肥胖引起的疾病的重要作用。PGC 1 α可能是未来预防和治疗肥胖引起的疾病的靶点，可能是通过增强线粒体生物合成和代谢。(C)2018年希腊心脏病学会。出版社：Elsevier B. V.
Objective: PGC-1 alpha is already known as a significant regulator of mitochondrial biogenesis, oxidative phosphorylation and fatty acid metabolism. Our study focuses on the role of PGC1 alpha in morbid obesity, in five different tissues, collected from 50 severely obese patients during planned bariatric surgery.Methods: The investigated tissues included subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), skeletal muscle (SM), extramyocellular adipose tissue (EMAT) and liver. PGC1 alpha expression was investigated with immunohistochemistry and evaluated with microscopy.Results: Our findings highlighted significant positive inter-tissue correlations regarding PGC-1 alpha expression between several tissue pairs (VAT-SAT, VAT-SM, VAT-EMAT, SAT-SM, SAT-EMAT, SM-EMAT). Moreover, we found significant negative correlations between PGC1 alpha expression in VAT with CD68 expression in skeletal muscle and EMAT, implying a possible protective role of PGC1 alpha against obesity-induced inflammation.Conclusion: Unmasking the inter-tissue communication networks regarding PGC-1 alpha expression in morbid obesity, will give more insight into its significant role in obesity-induced diseases. PGC1 alpha could potentially represent a future preventive and therapeutic target against obesity-induced disease, probably through enhancing mitochondrial biogenesis and metabolism. (C) 2018 Hellenic Society of Cardiology. Publishing services by Elsevier B.V.