Mitochondrial DNA gene therapy: a gene therapy for aging?
Mitochondrial DNA gene therapy: a gene therapy for aging?
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线粒体DNA基因疗法：抗衰老的基因疗法？
DOI：
10.1089/rej.2005.8.6
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发表时间：
2005
影响因子：
2.6
通讯作者：
Khrapko,Konstantin
中科院分区：
文献类型：
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作者：
Khrapko,Konstantin
线粒体DNA的突变导致一组不同的疾病，影响全世界估计有50万人。这些疾病对常规治疗具有显著的抗性，因此正在探索几种基因治疗方法。随着其中一些方法逐渐成熟，人们不禁会想到，有一天它们可能会被用于解决目前影响约60亿人的更常见的健康问题-老龄化，这也是对治疗的抵抗力。不幸的是，我们仍然不知道mtDNA突变是否会显著促进衰老过程。线粒体DNA基因治疗成功的前景使获得答案成为一个高度优先事项。
Mutations in mitochondrial DNA cause a group of diverse diseases that affect an estimated half a million people worldwide. These disorders are remarkably resistant to conventional treatments, and thus several gene therapy approaches are being explored. As some of these approaches develop towards maturity, one can't help thinking that some day they may be used against a much more common health problem currently affecting about 6 billion people— aging, which also has been quite resistant to treatment. Unfortunately, we still do not know whether mtDNA mutations significantly contribute to the aging process or not. The prospect of success in mtDNA gene therapy makes getting the answer a high priority.