AGE-RELATED-CHANGES IN CORTICAL AND CANCELLOUS VERTEBRAL BONE-DENSITY IN GIRLS - ASSESSMENT WITH QUANTITATIVE CT
AGE-RELATED-CHANGES IN CORTICAL AND CANCELLOUS VERTEBRAL BONE-DENSITY IN GIRLS - ASSESSMENT WITH QUANTITATIVE CT
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DOI：
10.2214/ajr.162.2.8310936
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发表时间：
1994-02-01
影响因子：
5
通讯作者：
GILSANZ, V
中科院分区：
文献类型：
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作者：
MORA, S;GOODMAN, WG;GILSANZ, V
OBJECTIVE.骨量在生长过程中增加，但关于骨骼发育过程中皮质骨和松质骨密度变化或其对年龄相关骨量增加的相对贡献的信息很少。因此，在儿童期和青春期的白色女孩性发育的每个阶段分别测量松质骨和皮质骨密度。主题和方法。应用定量CT测量了96例4-20岁健康白色女孩腰椎皮质骨和松质骨密度。然后研究各种人体测量指标、青春期状态和相应的皮质骨和松质骨密度之间的关系。结果皮质骨密度随年龄增长而增加，并且值与身高（r= 0.61）、体重（r= 0.62）、体重指数（r= 0.61）和肌肉体积（r= 0.58）等人体测量指标显著相关。相反，松质骨椎体骨密度增加，只有在青春期后期。此外，青春期前女孩的松质骨密度与年龄（r=-0.27）以及椎体体积（r=-0.20）和高度（r=-0.15）呈负相关。结论结果表明，承重和/或机械应力是整个生长过程中腰椎皮质骨密度的重要决定因素，而松质骨椎体骨密度更强烈地受到青春期后期与性发育相关的激素和/或代谢因素的影响。
OBJECTIVE. Bone mass increases during growth, but little information is available about the changes in cortical and cancellous bone densities during skeletal development or their relative contributions to age-related increases in bone mass. Accordingly, separate measurements of cancellous and cortical bone density were done at each stage of sexual development in white girls during childhood and adolescence. SUBJECTS AND METHODS. Quantitative CT was used to measure the densities of cortical and cancellous bone of the lumbar spine in 96 healthy white girls 4-20 years old. The relationships among various anthropometric indexes, pubertal status, and corresponding densities of cortical and cancellous bone were then examined. RESULTS. Cortical bone density increased with age, and values were significantly correlated with the anthropometric indexes of height (r=.61), weight (r=.62), body mass index (r=.61), and muscle volume (r=.58). In contrast, cancellous vertebral bone density increased only during the later stages of puberty. Moreover, cancellous bone density in prepubertal girls was inversely related to age (r= -.27) as well as to both the volume (r= -.20) and the height (r= -.15) of the vertebral body. CONCLUSION. The results suggest that weight bearing and/or mechanical stresses are important determinants of cortical bone density in the lumbar spine throughout growth, whereas cancellous vertebral bone density is more strongly influenced by hormonal and/or metabolic factors associated with sexual development during late adolescence.