Diffusion tensor imaging of the brain in a healthy adult population: Normative values and measurement reproducibility at 3 T and 1.5 T
Diffusion tensor imaging of the brain in a healthy adult population: Normative values and measurement reproducibility at 3 T and 1.5 T
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DOI：
10.3109/02841851.2010.495351
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发表时间：
2010-09-01
期刊：
影响因子：
1.3
通讯作者：
Dastidar, Prasun
中科院分区：
文献类型：
--
作者：
Brander, Antti;Kataja, Anneli;Dastidar, Prasun
背景资料：扩散张量成像（DTI）是一种越来越多地用于研究脑白色物质完整性的研究和临床应用的方法。当在临床患者中解释DTI测量时，熟悉各向异性分数（FA）和表观扩散系数（ADC）值的正常变化以及测量再现性至关重要。目的：根据感兴趣区（ROI）分析，确定健康成人人群在1.5 T和3 T MRI下FA和ADC的正常值，并研究测量的观察者间和观察者内重现性。材料和方法：40名健康志愿者（26名女性，14名男性，平均年龄38.3岁，SD 11.6岁）进行了常规MRI和DTI的大脑，30名使用3T和10名使用1.5T临床扫描仪。在每个半球的五个不同解剖位置和胼胝体内的三个位置进行基于ROI的FA和ADC值测量。计算每个区域的FA和ADC平均值。通过比较两个观察者的结果，观察者之间的变化的ROI测量进行了评价，观察者内的变化，由两个observers.Results重复测量10个主题：FA值在不同地区之间变化很大。最高值发现在胼胝体的胼胝体和压部和最低的辐射冠，分别。在一般情况下，ADC值表现出较小的变化，最高的值被发现在胼胝体的身体和最低的放射冠。观察者间和观察者内测量的重现性也因地区而异。最高的协议被发现为胼胝体和最低的放射冠和半卵圆centrum semiovale.Conclusion：在一个正常的成年人人群FA和ADC值的大脑白色物质显示区域性变化。ROI测量的可重复性也随区域而变化。在临床患者中解释这些测量值时，必须承认这种区域性差异。
Background: Diffusion tensor imaging (DTI) is an increasingly used method for investigation of brain white matter integrity in both research and clinical applications. Familiarity with normal variation of fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values and measurement reproducibility is essential when DTI measurements are interpreted in clinical patients.Purpose: To establish normal values for FA and ADC in a healthy adult population at 1.5 T and 3 T MRI based on region of interest (ROI) analysis, and to study the inter- and intra-observer reproducibility of the measurements.Material and Methods: Forty healthy volunteers (26 women, 14 men, mean age 38.3, SD 11.6 years) underwent conventional MRI and DTI of the brain, 30 with 3 T and 10 with 1.5 T clinical scanners. ROI-based measurements for FA and ADC values were performed in five different anatomic locations of each hemisphere and in three locations within the corpus callosum. Mean values for FA and ADC for each region were calculated. Inter-observer variation of ROI measurements was evaluated by comparing the results of the two observers, intra-observer variation by repeated measurement of 10 subjects by both observers.Results: The FA values varied considerably between different regions. The highest values were found in the genu and splenium of the corpus callosum and the lowest in the corona radiata, respectively. In general, ADC values showed less variation; the highest values were found in the body of the corpus callosum and the lowest in the corona radiata. The reproducibility of both inter- and intra-observer measurements also varied regionally. The highest agreement was found for the corpus callosum and the lowest for the corona radiata and centrum semiovale.Conclusion: In a normal adult population FA and ADC values of the brain white matter show regional variation. The repeatability of the ROI measurements also varies regionally. This regional variability must be acknowledged when these measurements are interpreted in clinical patients.