A Human Experimental Bone Pain Model
A Human Experimental Bone Pain Model
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DOI：
10.1111/bcpt.12002
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发表时间：
2013-02-01
影响因子：
3.1
通讯作者：
Arendt-Nielsen, Lars
中科院分区：
文献类型：
--
作者：
Andresen, Trine;Pfeiffer-Jensen, Mogens;Arendt-Nielsen, Lars
本研究的目的是建立一种人类实验性骨痛模型。14名健康男性被纳入两个研究阶段。使用不同尺寸的探针估计压痛阈值（PPT）。计算机控制的和手持痛觉测量应用于皮肤局部麻醉（LA）前后，覆盖右侧和左侧胫骨内侧的皮肤区域，并评价再现性。比较了健康志愿者和12例椎体骨折患者的疼痛体验（麦吉尔问卷）。计算机控制的痛觉计：对于6 mm和8 mm探头，研究期间的PPT无差异（p = 0.43和0.32）。对于6 mm穿刺针，LA前后的PPT存在差异（p = 0.008），但对于8 mm穿刺针则无差异（p = 0.26）。手持式痛觉计：对于4 mm和8 mm穿刺针，观察到研究阶段之间的PPT差异（p = 0.03和0.007），但对于2 mm、6 mm和10 mm穿刺针，没有观察到差异（p = 0.19、0.05和0.25）。对于2、4、8和10 mm探头，LA前后的PPT无差异（p = 0.35、0.15、0.08和0.53），但LA显著影响6 mm探头的PPT（p = 0.01）。健康志愿者和患者在麦吉尔疼痛问卷中选择相似的词，定性描述深度疼痛感。由手持式痛觉计和2 mm探头引起的疼痛不受LA的影响，PPT在会话之间是可重复的，推荐用于实验诱发的骨相关疼痛的研究。
The aim of this study was to develop a human experimental bone pain model. Fourteen healthy men were included in two study sessions. Pressure pain threshold (PPT) was estimated using probes of different sizes. Computer-controlled and hand-held algometry were applied to the skin area covering right and left medial tibia before and after local anaesthesia (LA) of the skin and reproducibility was evaluated. Pain experience (McGill questionnaire) was compared between healthy volunteers and 12 patients with vertebral fractures. Computer-controlled algometer: No differences in PPT between study sessions for 6 and 8-mm probes (p = 0.43 and 0.32) were seen. There was a difference in PPT before and after LA for the 6-mm probe (p = 0.008), but not for the 8-mm probe (p = 0.26). Hand-held algometer: A difference in PPT between study sessions was observed for 4- and 8-mm probes (p = 0.03 and 0.007), but not for 2, 6 and 10-mm probes (p = 0.19, 0.05 and 0.25). No differences in PPT were seen before and after LA for 2, 4, 8 and 10-mm probes (p = 0.35, 0.15, 0.08 and 0.53), but LA significantly influenced PPT with the 6-mm probe (p = 0.01). Similar words were chosen in the McGill pain questionnaire by healthy volunteers and patients, qualitatively describing the deep pain sensation. The pain evoked by hand-held algometer and the 2-mm probe was not influenced by LA, and PPT was reproducible between sessions and is recommended for studies of experimentally evoked bone-associated pain.