Characterization of the chitin biosynthesis process as a compensatory mechanism in the fks1 mutant of Saccharomyces cerevisiae
Characterization of the chitin biosynthesis process as a compensatory mechanism in the fks1 mutant of Saccharomyces cerevisiae
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DOI：
10.1016/s0014-5793(00)01835-4
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发表时间：
2000-07-28
期刊：
影响因子：
3.5
通讯作者：
Roncero, C
中科院分区：
文献类型：
--
作者：
García-Rodriguez, LJ;Trilla, JA;Roncero, C
酿酒酵母中1，3-β-D-葡聚糖合酶基因FKS 1的缺失诱导了一种补偿机制，其反映在几丁质合酶III（CSIII）活性的显著增加中，导致几丁质合成的高速率。CSIII活性的失调主要是由于CSIII活性复合物的两个主要组分Chs 3 p和Chs 4p的细胞内离域。(C)2000欧洲生物化学学会联合会，由Elsevier Science B. V.出版，版权所有。
Deletion of the 1,3-beta-D-glucan synthase gene FKS1 in Saccharomyces cerevisiae induces a compensatory mechanism that is reflected in a significant increase in chitin synthase III (CSIII) activity, leading to high rates of chitin synthesis. Deregulation of CSIII activity is mainly due to the intracellular delocalization of Chs3p and Chs4p, the two main components of the CSIII active complex. (C) 2000 Federation of European Biochemical Societies, Published by Elsevier Science B.V. All rights reserved.