Contrast enhanced-cardiovascular magnetic resonance imaging in patients with pulmonary hypertension
Contrast enhanced-cardiovascular magnetic resonance imaging in patients with pulmonary hypertension
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DOI：
10.1093/eurheartj/ehi328
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发表时间：
2005-10-01
影响因子：
39.3
通讯作者：
Peacock, AJ
中科院分区：
文献类型：
--
作者：
Blyth, KG;Groenning, BA;Peacock, AJ
目的应用对比剂增强心血管磁共振成像（ce-CMR）确定肺动脉高压（PHT）患者延迟对比剂增强（DCE）的存在和程度。用ce-CMR测定右心室（RV）和左心室（LV）容积、射血分数、质量和DCE质量。平均肺动脉压（平均PAP）为43（12）mmHg，心输出量为4.3（1.2）L/min。25例患者中有23例显示DCE。7例患者的DCE局限于RV插入点（RVIP），其余16例患者延伸至室间隔（IVS）。在这16例患者中，间隔对比增强与IVS弯曲相关。对比增强程度与RV舒张末期容积/体表面积、RV质量、平均PAP和肺血管阻力呈正相关，与RV射血分数呈负相关。结论大多数PHT患者的RVIP和IVS内存在VCE。DCE的程度与RV功能和肺血流动力学相关。DCE与IVS弯曲相关，可能为这些患者经历的与血流动力学应激直接相关的隐匿性间隔异常提供新的标志物。
Aims To determine the presence and extent of delayed contrast enhancement (DCE) in patients with pulmonary hypertension (PHT) using contrast enhanced-cardiovascular magnetic resonance imaging (ce-CMR).Methods and results Twenty-five patients with PHT underwent ce-CMR and right heart catheterization. Right ventricular (RV) and left ventricular (LV) volumes, ejection fraction, mass, and DCE mass were determined with ce-CMR. Mean pulmonary artery pressure (mean PAP) averaged 43 (12) mmHg and cardiac output 4.3 (1.2) L/min. DCE was demonstrated in 23 out of 25 patients. DCE was confined to the RV insertion points (RVIPs) in seven patients and extended into the interventricular septum (IVS) in the remaining 16 patients. In these 16 patients, septal contrast enhancement was associated with IVS bowing. The extent of contrast enhancement correlated positively with RV end-diastolic volume/body surface area, RV mass, mean PAP, and pulmonary vascular resistance and correlated inversely with RV ejection fraction.Conclusion DCE was present within the RVIPs and IVS of most patients with PHT studied. Extent of DCE correlated with RV function and pulmonary haemodynamics. DCE was associated with IVS bowing and may provide a novel marker for occult septal abnormalities directly relating to the haemodynamic stress experienced by these patients.