Clinical Course and Management of Dengue in Children Admitted to Hospital A 5 Years Prospective Cohort Study in Jakarta, Indonesia
Clinical Course and Management of Dengue in Children Admitted to Hospital A 5 Years Prospective Cohort Study in Jakarta, Indonesia
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DOI：
10.1097/inf.0000000000002479
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发表时间：
2019-12-01
影响因子：
3.6
通讯作者：
Bruijning-Verhagen, Patricia
中科院分区：
文献类型：
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作者：
Karyanti, Mulya Rahma;Uiterwaal, Cuno S. P. M.;Bruijning-Verhagen, Patricia
背景：全球登革热发病率正在上升，估计每年有 1 亿例，而印度尼西亚估计每年有 750 万例。登革热临床病程从轻度登革热（DF）到登革出血热（DHF）或登革休克综合征（DSS）不等。如果可靠的预测因子能够在入院时确定哪些临床疑似登革热病例将进展为 DHF 或 DSS，那么患者、临床医生和护理机构将会受益。方法：从 2009 年到 2013 年，对印度尼西亚雅加达一家三级护理医院收治的 494 名临床疑似登革热儿童进行随访直至出院。我们评估了入院患者的临床病程和疾病结果，并估计了住院登革热病例随时间推移的负担。结果：在所有 494 名儿童中，入院时 185 名 (37%) 被分类为 DF，158 名 (32%) 被分类为 DHF，151 名 (31%) 被分类为 DSS。在 DF 患者中，52 例（28%）进展为 DHF 或 DSS，10 例（5%）患有其他病毒性疾病。在 DHF 患者中，9 例（6%）进展为 DSS。入院时常规收集的 33 个参数中，发烧持续时间
Background: Dengue incidence is rising globally which was estimated 100 million per year, whereas in Indonesia was estimated 7.5 million per year. Dengue clinical course varies from mild dengue fever (DF) to dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). Patients, clinicians and care facilities would benefit if reliable predictors can determine at admission which cases with clinically suspected dengue will progress to DHF or DSS. Methods: From 2009 through 2013, a cohort of 494 children admitted with clinically suspected dengue at a tertiary care hospital in Jakarta, Indonesia, was followed until discharge. We evaluated the clinical course and disease outcome of admitted patients and estimated the burden of dengue cases hospitalized over time. Results: Of all 494 children, 185 (37%) were classified at admission as DF, 158 (32%) as DHF and 151 (31%) as DSS. Of DF patients, 52 (28%) progressed to DHF or DSS, 10 (5%) had other viral diseases. Of DHF patients, 9(6%) progressed to DSS. Of 33 routinely collected parameters at admission, duration of fever