Catalytic asymmetric silane alcoholysis: practical access to chiral silanes.
Catalytic asymmetric silane alcoholysis: practical access to chiral silanes.
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DOI：
10.1021/ja0283201
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发表时间：
2003-01
影响因子：
15
通讯作者：
Darby R Schmidt;Steven J. O'Malley;J. L. Leighton
中科院分区：
文献类型：
--
作者：
Darby R Schmidt;Steven J. O'Malley;J. L. Leighton
发展了一种新的手性硅烷的不对称合成方法。手性膦修饰的铜配合物催化前手性二氢硅烷的醇解，在硅上具有良好到优异的立体选择性。该方法在炔的甲硅烷基甲酰化-烯丙基甲硅烷基化串联反应中的应用已得到证实。
A new asymmetric synthesis of chiral silanes has been developed. Chiral phosphine-modified copper complexes catalyze the alcoholysis of prochiral dihydrosilanes with good to excellent stereoselectivity at silicon. The application of this methodology to the tandem silylformylation-allylsilylation of alkynes has been demonstrated.