Central auditory plasticity: Changes in the N1-P2 complex after speech-sound training
Central auditory plasticity: Changes in the N1-P2 complex after speech-sound training
复制标题
DOI：
10.1097/00003446-200104000-00001
复制
发表时间：
2001-04-01
期刊：
影响因子：
3.7
通讯作者：
Otis, B
中科院分区：
文献类型：
--
作者：
Tremblay, K;Kraus, N;Otis, B
目的：为了确定N1-P2复合波是否反映了训练引起的神经活动的改变，与改善发声时间(VOT)知觉有关，设计：从10名听力正常的年轻人获得听觉皮质诱发电位N1和P2，采用重复测量设计，在训练前后对受试者进行行为和神经生理测试，以确定是否存在训练相关的变化。在测试前和测试后之间，受试者被训练以区分-20毫秒和-10毫秒的vot\ba\音节。在电生理测试中使用两种刺激呈现速率(390毫秒和910毫秒的刺激间隔)。结果：训练前，受试者将-20毫秒和-10毫秒的VOT刺激识别为/ba，通过训练，被试学会将-20毫秒的VOT刺激识别为“MBA”，将-10毫秒的VOT刺激识别为“ba”。当受试者学会正确识别-20毫秒和-10毫秒VOT教学大纲之间的差异时，观察到N1-P2峰间波幅的增加。结论：随着知觉的提高，N1-P2波幅增加。波形形态的这些变化被认为反映了神经同步性的增强，以及与语音感知改善相关的神经连接的加强。这些发现表明，N1-P2复合体可能作为与语音-声音训练相关的语音-声音表征的客观生理关联而具有临床应用价值。
Objective: To determine whether the N1-P2 complex reflects training-induced changes in neural activity associated with improved voice-onset-time (VOT) perception,Design: Auditory cortical evoked potentials N1 and P2 were obtained from 10 normal-hearing young adults in response to two synthetic speech variants of the syllable \ba\, Using a repeated measures design, subjects were tested before and after training both behaviorally and neurophysiologically to determine whether there were training-related changes. In between pre- and post-testing sessions, subjects were trained to distinguish the -20 and -10 msec VOT \ba\ syllables as being different from each other. Two stimulus presentation rates were used during electrophysiologic testing (390 msec and 910 msec interstimulus interval).Results: Before training, subjects perceived both the -20 msec and -10 msec VOT stimuli as /ba\, Through training, subjects learned to identify the -20 msec VOT stimulus as "mba" and -10 msec VOT stimulus as "ba." As subjects learned to correctly identify the difference between the -20 msec and -10 msec VOT syllabi, an increase in N1-P2 peak-to-peak amplitude was observed. The effects of training were most obvious at the slower stimulus presentation rate.Conclusions: As perception improved, N1-P2 amplitude increased. These changes in waveform morphology are thought to reflect increases in neural synchrony as well as strengthened neural connections associated with improved speech perception. These findings suggest that the N1-P2 complex may have clinical applications as an objective physiologic correlate of speech-sound representation associated with speech-sound training.