Peptide YY and the Y2 agonist PYY-(13-36) inhibit neurons of the dorsal motor nucleus of the vagus.
Peptide YY and the Y2 agonist PYY-(13-36) inhibit neurons of the dorsal motor nucleus of the vagus.
复制标题
肽 YY 和 Y2 激动剂 PYY-(13-36) 抑制迷走神经背侧运动核的神经元。
DOI：
10.1152/ajpregu.1997.273.1.r213
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Rogers,RC
中科院分区：
文献类型：
--
作者：
Chen,CH;Rogers,RC
肽YY （PYY）是由回肠内分泌细胞对肠腔内脂肪酸的存在作出反应而释放的。循环PYY抑制迷走神经介导的消化功能，这是直接作用于髓质背侧神经元的结果。我们实验室最近的证据表明，pyy介导的消化抑制发生是因为肽作用于髓背区包围迷走反射回路的y2型受体。本研究描述了PYY和特异性Y2激动剂肽PYY-（13-36)对迷走神经背运动核（DMN）神经元在1）完整的体内和2)体外脑干切片制备中的作用。我们的研究结果表明，在体内或体外条件下记录的50%的DMN神经元，包括突触阻断，被PYY或PYY-的应用抑制（13-36）。大约45%的病毒不受影响，只有大约5%的病毒被激活。这些结果表明，PYY抑制消化功能的主要手段之一是通过作用于Y2受体直接抑制DMN的胆碱能迷走神经传出神经元。
Peptide YY (PYY) is released by endocrine cells in the ileum in response to the presence of fatty acids in the intestinal lumen. Circulating PYY suppresses vagally mediated digestive functions as a consequence of direct action on neurons in the dorsal medulla. Recent evidence from our laboratory suggests that this PYY-mediated inhibition of digestion occurs because of peptide action at the Y2-type receptor in the dorsal medullary region encompassing vago-vagal reflex circuitry. The present study describes the effects of PYY and the specific Y2 agonist peptide PYY-(13-36) on neurons of the dorsal motor nucleus of the vagus (DMN) in both the 1) intact in vivo and 2) in vitro brain stem slice preparation. Our results show that 50% of DMN neurons recorded under in vivo or in vitro conditions, including synaptic blockade, are inhibited by the application of PYY or PYY-(13-36). Approximately 45% are not affected, and only approximately 5% are activated. These results suggest that one of the principal means by which PYY suppresses digestive functions is by the direct inhibition of cholinergic vagal efferent neurons of the DMN via action at a Y2 receptor.