Toward identification of neural markers of suicide risk in adolescents.
Toward identification of neural markers of suicide risk in adolescents.
复制标题
识别青少年自杀风险的神经标志物。
DOI：
10.1038/npp.2013.233
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Phillips,MaryL
中科院分区：
文献类型：
--
作者：
Pan,LisaA;Phillips,MaryL
自杀仍然是青少年发病和死亡的主要原因。尽管确定了自杀行为的风险因素和保护因素，但我们对自杀未遂风险的机制了解有限。青春期是自杀行为的高风险时期，也是干预和治疗可能产生最大影响的时期，因为这一时期的大脑结构变化和显著的心理社会发展。功能性磁共振成像（fMRI）研究有望产生青少年自杀行为风险的标志物，因为它们可以帮助识别在行为水平上无法观察到的病理生理机制的神经生物学基础，并且还可以为未来的神经生物学干预提供目标。自杀行为的风险标志物开始被阐明，但尚未被应用于有自杀风险的青少年的临床管理。
Suicide remains a leading cause of adolescent morbidity and mortality. Despite identification of risk factors and protective factors for suicidal behavior, we have limited understanding of the mechanisms underlying risk for suicide attempt. Adolescence is a time of high risk for suicidal behavior, as well as a time that intervention and treatment may have the greatest impact because of structural brain changes and significant psychosocial development during this period. Functional magnetic resonance imaging (fMRI) studies have promise to yield markers of risk for suicidal behavior in adolescents because they can help identify neurobiological underpinnings of pathophysiologic mechanisms that are not observable at the behavioral level, and can also provide targets for future neurobiological interventions. Markers of risk for suicidal behavior are beginning to be elucidated, but as yet have not been applied to the clinical management of adolescents at risk for suicide.