Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese population
Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese population
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DOI：
10.1038/jhg.2010.99
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发表时间：
2010-11-01
影响因子：
3.5
通讯作者：
Kamatani, Naoyuki
中科院分区：
文献类型：
--
作者：
Hotta, Kikuko;Nakamura, Michihiro;Kamatani, Naoyuki
代谢综合征的主要风险因素是腹内脂肪积聚，其通过腰围和腰臀比测量以及通过计算机断层扫描（CT）测量的内脏脂肪面积（VFA）确定。有证据表明，高加索人群的腰围和腰臀比与几种基因的变异有关，包括神经毒素3（NRXN 3）、转录因子AP-2 β（TFAP 2B）、甲硫氨酸亚砜还原酶A（MSRA）、溶血磷脂酶样-1（LYPLAL 1）、脂肪量和肥胖相关（FTO）和黑皮质素4受体（MC 4 R）基因。为了研究招募的日本人群中VFA和皮下脂肪面积（SFA）与这些基因之间的关系，我们对来自1228名受试者的这6个基因中的8个单核苷酸多态性（SNPs）进行了基因分型。多元回归分析显示，性别、年龄和FTO中rs 1558902和rs 1421085基因型（相加模型）与体重指数（BMI; P=0.0039和0.0039）、SFA（P=0.0027和0.0023）和VFA（P=0.045和0.040）显著相关。然而，其他基因，即NRXN 3，TFAP 2B，MSRA，LYPLAL 1和MC 4 R中的SNP与BMI，SFA或VFA无显著相关性。我们的数据表明，在高加索人全基因组研究中发现的一些SNPs也使日本受试者对脂肪分布易感。Journal of Human Genetics（2010）55，738-742; doi：10.1038/jhg.2010.99; 2010年8月12日在线发表
The predominant risk factor of metabolic syndrome is intra-abdominal fat accumulation, which is determined by waist circumference and waist-hip ratio measurements and visceral fat area (VFA) that is measured by computed tomography (CT). There is evidence that waist circumference and waist-hip ratio in the Caucasian population are associated with variations in several genes, including neurexin 3 (NRXN3), transcription factor AP-2 beta (TFAP2B), methionine sulfoxide reductase A (MSRA), lysophospholipase-like-1 (LYPLAL1), fat mass and obesity associated (FTO) and melanocortin 4 receptor (MC4R) genes. To investigate the relationship between VFA and subcutaneous fat area (SFA) and these genes in the recruited Japanese population, we genotyped 8 single-nucleotide polymorphisms (SNPs) in these 6 genes from 1228 subjects. Multiple regression analysis revealed that gender, age, and rs1558902 and rs1421085 genotypes (additive model) in FTO were significantly associated with body mass index (BMI; P=0.0039 and 0.0039, respectively), SFA (P=0.0027 and 0.0023, respectively) and VFA (P=0.045 and 0.040, respectively). However, SNPs in other genes, namely, NRXN3, TFAP2B, MSRA, LYPLAL1 and MC4R were not significantly associated with BMI, SFA or VFA. Our data suggest that some SNPs, which were identified in genome-wide studies in the Caucasians, also confer susceptibility to fat distribution in the Japanese subjects. Journal of Human Genetics (2010) 55, 738-742; doi:10.1038/jhg.2010.99; published online 12 August 2010