Ultimate resolution for refractometric sensing with whispering gallery mode microcavities
Ultimate resolution for refractometric sensing with whispering gallery mode microcavities
复制标题
DOI：
10.1364/oe.20.008284
复制
发表时间：
2012-04-09
期刊：
影响因子：
3.8
通讯作者：
Meldrum, A.
中科院分区：
文献类型：
--
作者：
Silverstone, J. W.;McFarlane, S.;Meldrum, A.
许多提出的微流体生物传感器设计是基于光学微腔共振的测量。基于荧光的谐振器往往比使用可调谐激光的倏逝耦合来探测腔体的装置更简单、更坚固。在所有的传感器设计中，检测限取决于检测系统的波长分辨率，这是基于荧光的设备的限制。在这项工作中，我们探索了折射微腔传感器结构的最终分辨率和检测极限。由于从荧光谐振器中同时收集了许多周期模式，因此标准傅立叶方法可以最适合于快速和精确地分析谐振移位。找到了计算传感器最终分辨率和检测限的简单数值表达式，并将结果与荧光核微血管共振响应水中不同蔗糖浓度的实验结果进行了比较。(C) 2012美国光学学会
Many proposed microfluidic biosensor designs are based on the measurement of the resonances of an optical microcavity. Fluorescence-based resonators tend to be simpler and more robust than setups that use evanescent coupling from tuneable laser to probe the cavity. In all sensor designs the detection limits depend on the wavelength resolution of the detection system, which is a limitation of fluorescence-based devices. In this work, we explore the ultimate resolution and detection limits of refractometric microcavity sensor structures. Because many periodic modes are collected simultaneously from fluorescent resonators, standard Fourier methods can be best suited for rapid and precise analysis of the resonance shifts. Simple numerical expressions to calculate the ultimate sensor resolution and detection limits were found, and the results compared to experiments in which the resonances of fluorescent-core microcapillaries responded to various sucrose concentrations in water. (C) 2012 Optical Society of America