A framework for interpreting genome-wide association studies of psychiatric disorders The Psychiatric GWAS Consortium Steering Committee
A framework for interpreting genome-wide association studies of psychiatric disorders The Psychiatric GWAS Consortium Steering Committee
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DOI：
10.1038/mp.2008.126
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发表时间：
2009-01-01
影响因子：
11
通讯作者：
Sullivan, Patrick F.
中科院分区：
文献类型：
--
作者：
Cichon, Sven;Craddock, Nick;Sullivan, Patrick F.
全基因组关联研究（GWAS）在过去的3年中产生了大量的新发现。到2009年初，将完成对47名患有注意力缺陷多动障碍、自闭症、双相情感障碍、重度抑郁症和精神分裂症的受试者样本的GWAS。总而言之，这些GWAS构成了精神病学领域有史以来最大的生物学实验（59，000个独立病例和对照、7，700个家庭三重奏和超过400亿个基因型）。我们知道GWAS可以工作，现在的问题是它是否适用于精神疾病。在这篇综述中，我们描述了这些研究，精神病学GWAS联盟对这些数据进行荟萃分析，并提供了一个逻辑框架来解释一些可能的结果。
Genome-wide association studies (GWAS) have yielded a plethora of new findings in the past 3 years. By early 2009, GWAS on 47 samples of subjects with attention-deficit hyperactivity disorder, autism, bipolar disorder, major depressive disorder and schizophrenia will be completed. Taken together, these GWAS constitute the largest biological experiment ever conducted in psychiatry ( 59 000 independent cases and controls, 7700 family trios and > 40 billion genotypes). We know that GWAS can work, and the question now is whether it will work for psychiatric disorders. In this review, we describe these studies, the Psychiatric GWAS Consortium for meta-analyses of these data, and provide a logical framework for interpretation of some of the conceivable outcomes.