Visual acuity, contrast sensitivity, and mortality in older women: Study of osteoporotic fractures
Visual acuity, contrast sensitivity, and mortality in older women: Study of osteoporotic fractures
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DOI：
10.1111/j.1532-5415.2006.00983.x
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发表时间：
2006-12-01
影响因子：
6.3
通讯作者：
Mangione, Carol M.
中科院分区：
文献类型：
--
作者：
Pedula, Kathryn L.;Coleman, Anne L.;Mangione, Carol M.
目的：确定视力和对比敏感度差是否是老年妇女全因死亡和创伤死亡的独立危险因素。设计：10年前瞻性队列研究地点：4个美国临床中心，参与者：9704名年龄在65岁及以上的绝经后白色妇女。在基线时使用标准方案测量习惯性矫正的双眼视力和低频和高频对比敏感度。研究医生根据死亡证明和医疗记录审查判定主要死亡原因。结果：在平均12.2年的随访中，3,427名妇女死亡（35%），72名（0.7%）死于创伤事件。在校正了年龄、慢性疾病和吸烟的多变量模型中，视力最差四分位数的人的全因死亡风险比视力最好的人高19%（风险比（HR）= 1.19，P = 0.008），对比敏感度最差的人的全因死亡风险比视力最好的人高39%（HR = 1.39，P = 0.008）。
OBJECTIVES: To determine whether poorer visual acuity and contrast sensitivity are independent risk factors for all-cause and traumatic mortality in older women.DESIGN: Twelve-year prospective cohort study (1986-2003).SETTING: Four U.S. clinical centers.PARTICIPANTS: Nine thousand seven hundred four postmenopausal white women aged 65 and older.MEASUREMENTS: Habitually corrected binocular visual acuity and low- and high-frequency contrast sensitivity were measured at baseline using a standard protocol. A study physician adjudicated the primary cause of death from death certificates and medical record review.RESULTS: During an average of 12.2 years of follow-up, 3,427 women died (35%), 72 (0.7%) from traumatic events. In multivariate models adjusted for age, chronic medical problems, and smoking, all-cause mortality risk was 19% greater for persons in the worst quartile of visual acuity than for those in the best (hazard ratio (HR) = 1.19, P =.008) and 39% greater for persons with the worst contrast sensitivity (HR = 1.39, P