Calcium intake and body weight.
Calcium intake and body weight.
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DOI：
10.1210/jcem.85.12.7063
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发表时间：
2000-12
期刊：
影响因子：
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通讯作者：
K. Davies;R. Heaney;R. Recker;J. Lappe;M. Barger-Lux;K. Rafferty;S. Hinders
中科院分区：
文献类型：
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作者：
K. Davies;R. Heaney;R. Recker;J. Lappe;M. Barger-Lux;K. Rafferty;S. Hinders
重新评估了以主要骨骼终点为设计目标的五项钙摄入量临床研究，以探索钙摄入量与体重之间的关联。所有受试者均为女性，分为三个主要年龄组：3 岁、5 岁和 8 岁。总样本量为 780。其中四项研究是观察性的；四项是观察性的。两个是横截面的，其中体重指数根据入门水平的钙摄入量进行回归；两个是纵向的，其中体重随时间的变化与钙摄入量进行回归。一项研究是一项双盲、安慰剂对照、随机补钙试验，其中将研究过程中的体重变化作为治疗状态的函数进行评估。在所有三个年龄组中，钙摄入量与体重之间均发现显着负相关，年轻女性超重（体重指数>26）的优势比为2.25，处于各自研究组钙摄入量的下半部分（P：<0.02）。相对于安慰剂，对照试验中接受钙治疗的受试者在近 4 年的观察中表现出显着的体重减轻。对这种关系的估计表明，1000 毫克钙摄入量差异与平均体重 8 公斤差异相关，并且钙摄入量解释了大约 3% 的体重差异。
Five clinical studies of calcium intake, designed with a primary skeletal end point, were reevaluated to explore associations between calcium intake and body weight. All subjects were women, clustered in three main age groups: 3rd, 5th, and 8th decades. Total sample size was 780. Four of the studies were observational; two were cross-sectional, in which body mass index was regressed against entry level calcium intake; and two were longitudinal, in which change in weight over time was regressed against calcium intake. One study was a double-blind, placebo-controlled, randomized trial of calcium supplementation, in which change in weight during the course of study was evaluated as a function of treatment status. Significant negative associations between calcium intake and weight were found for all three age groups, and the odds ratio for being overweight (body mass index, >26) was 2.25 for young women in the lower half of the calcium intakes of their respective study groups (P: < 0.02). Relative to placebo, the calcium-treated subjects in the controlled trial exhibited a significant weight loss across nearly 4 yr of observation. Estimates of the relationship indicate that a 1000-mg calcium intake difference is associated with an 8-kg difference in mean body weight and that calcium intake explains approximately 3% of the variance in body weight.