Intra-allelic mutation at human telomeres
Intra-allelic mutation at human telomeres
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DOI：
10.1042/bst0340581
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发表时间：
2006-08-01
影响因子：
3.9
通讯作者：
Baird, D. M.
中科院分区：
文献类型：
--
作者：
Britt-Compton, B.;Baird, D. M.
端粒长度的维持对于维护基因组的完整性是重要的。然而，从端粒长度和内部重复结构的详细观察中可以清楚地看出，人类端粒是非常动态的结构，并且经历了产生相当大的异质性的多个过程。遗传学证据表明，端粒内的减数分裂重组是罕见的。然而，有各种各样的证据表明，人类端粒动力学中的等位基因内过程的参与。在本文中，我们简要地回顾了一些证据和等位基因内端粒突变的假定机制。
The maintenance of telomere length is important in upholding the integrity of the genome. However, it is clear from detailed observations of both telomere length and internal repeat structure that human telomeres are extremely dynamic structures and are subjected to multiple processes that create considerable heterogeneity. Genetic evidence suggests that meiotic recombination within telomeres is rare. However, there are various lines of evidence that implicate the involvement of intra-allelic processes in human telomere dynamics. in this paper, we briefly review some of this evidence and the putative mechanisms of intra-allelic telomeric mutation.