Immunohistochemical expression and clinical significance of P-glycoprotein in previously untreated extranodal NK/T-cell lymphoma, nasal type
Immunohistochemical expression and clinical significance of P-glycoprotein in previously untreated extranodal NK/T-cell lymphoma, nasal type
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DOI：
10.1002/ajh.21256
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发表时间：
2008-10-01
影响因子：
12.8
通讯作者：
Guo, Ye
中科院分区：
文献类型：
--
作者：
Wang, Biyun;Li, Xiao-Qiu;Guo, Ye
P-糖蛋白（P-gp）在NK细胞和NK恶性肿瘤中的过表达已被多种方法鉴定。本研究的目的是确定P-gp在既往未经治疗的鼻型结外NK/T细胞淋巴瘤中的临床意义。来自30例最初接受CHOP或基于CHOP的化疗的患者的肿瘤标本通过免疫组化使用识别P-gp分子的细胞内表位的单克隆抗体JSB-1进行检查。P-gp阳性表达20例（67%）。P-gp阳性患者的完全缓解率明显低于P-gp阴性患者（20% vs.60%，P = 0.045）。中位随访时间为25个月，所有患者的2年无进展生存期（PFS）和总生存期（OS）分别为66%和69%。与P-gp阳性患者的PFS和OS率相比，P-gp阴性患者的PFS和OS率显示出获益趋势，但未达到临界P值的统计学显著性（PFS：90% vs. 54%，P = 0.1057; OS：90% vs. 61%，P = 0.2028）。我们的研究结果表明，P-gp表达与结外鼻型NK/T细胞淋巴瘤的不良治疗结果有关。
Overexpression of P-glycoprotein (P-gp) has been identified by a variety of methods in NK cells and NK malignancies. The aim of this study was to determine the clinical significance of P-gp in previously untreated extranodal NK/T cell lymphoma, nasal type. Tumor specimens from 30 patients initially treated with CHOP or CHOP-based chemotherapy were examined by immunohistochemistry using JSB-1, a monoclonal antibody recognizing the intracellular epitope of P-gp molecule. Twenty cases (67%) were positive for P-gp expression. The complete response rate achieved in P-gp positive patients was significantly lower than in P-gp negative ones (20% vs. 60%, P = 0.045). With a median follow-up of 25 months, the 2-year progression-free survival (PFS) and overall survival (OS) rates for all patients were 66 and 69%, respectively. Compared with both PFS and OS rates of P-gp positive patients, those of P-gp negative patients showed a trend of benefit that did not reach statistical significance for borderline P values (PFS: 90% vs. 54%, P = 0.1057; OS: 90% vs. 61%, P = 0.2028). Our results suggest that P-gp expression is related with poor treatment outcomes of extranodal NK/T cell lymphoma, nasal type.