Comparison of adenosine, isoflurane, and desflurane on myocardial tissue oxygen pressure during coronary artery constriction in dogs
Comparison of adenosine, isoflurane, and desflurane on myocardial tissue oxygen pressure during coronary artery constriction in dogs
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DOI：
10.1016/s1053-0770(03)00156-3
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发表时间：
2003-08-01
影响因子：
2.8
通讯作者：
Jonjev, ZS
中科院分区：
文献类型：
--
作者：
Hoffman, WE;Albrecht, RF;Jonjev, ZS
目的：比较腺苷、异氟醚或地氟醚诱导的低血压伴或不伴左前降支（LAD）冠状动脉缩窄对犬心肌组织氧分压（PmO2）的影响。设计：前瞻性、随机、非盲。设置：大学教学医院。参与者：雄性非目的繁殖犬（n = 18）。干预：用1.5%异氟烷（n = 12）或8%地氟烷（n = 6）麻醉犬。将流量探头和球囊封堵器放置在LAD动脉上。将测量心肌氧分压的探头插入LAD区域的中间心肌。心肌耗氧量（MVO2）计算为LAD流量×动脉减去冠状窦oxygencontent.Measures和主要结果：在腺苷输注，2.8%异氟醚，或14%地氟醚与或不与LAD收缩降低血流30%产生的低血压期间进行测量。在没有LAD动脉收缩的情况下，腺苷输注使LAD流量增加90%，MVO 2增加70%，2.8%异氟烷对MVO 2没有变化，14%地氟烷使MVO 2减少25%，但没有治疗改变PMO 2。LAD动脉收缩本身使PMO2下降50%。腺苷使心肌组织氧分压降低60%，2.8%异氟醚无明显变化，14%地氟醚使心肌组织氧分压升高100%。结论：腺苷、2.8%异氟醚和14%地氟醚对心肌缺血时MVO2和PMO2的影响呈负相关。这与增加需氧量导致心肌缺血的报道一致。(C)2003年爱思唯尔公司All rights reserved.
Objective: To compare adenosine-, isoflurane-, or desflurane-induced hypotension with and without left anterior descending (LAD) coronary artery constriction for the effects on myocardial tissue oxygen pressure (PmO2) in dogs.Design: Prospective, randomized, nonblinded.Setting: University teaching hospital.Participants: Male nonpurpose-bred dogs (n = 18).Interventions: Dogs were anesthetized with 1.5% isoflurane (n = 12) or 8% desflurane (n = 6). A flow probe and balloon occluder were placed on the LAD artery. A probe that measured myocardial oxygen pressure was inserted into the middle myocardium in the LAD region. Myocardial oxygen consumption (MVO2) was calculated as LAD flow x arterial minus coronary sinus oxygen content.Measures and Main Results: Measures were made during hypotension produced by adenosine infusion, 2.8% isoflurane, or 14% desflurane with and without LAD constriction to decrease blood flow 30%. Without LAD artery constriction, adenosine infusion increased LAD flow 90% and MVO2 70%,2.8% isoflurane produced no change in MVO2, and 14% desflurane decreased MVO2 25%, but no treatment changed PMO2. LAD artery constriction decreased PMO2 50% by itself. Adenosine infusion during LAD constriction decreased tissue oxygen pressure an additional 60%, 2.8% isoflurane produced no change, and 14% desflurane increased PMO2 100%.Conclusion: There was an inverse relationship between the effect of adenosine, 2.8% isoflurane, and 14% desflurane on MVO2 and PMO2 during ischemia. This is consistent with reports that increasing oxygen demand worsens myocardial ischemia. (C) 2003 Elsevier Inc. All rights reserved.