LOOPS IN GLOBULAR-PROTEINS - A NOVEL CATEGORY OF SECONDARY STRUCTURE
LOOPS IN GLOBULAR-PROTEINS - A NOVEL CATEGORY OF SECONDARY STRUCTURE
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DOI：
10.1126/science.3775366
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发表时间：
1986-11-14
期刊：
影响因子：
56.9
通讯作者：
ROSE, GD
中科院分区：
文献类型：
--
作者：
LESZCZYNSKI, JF;ROSE, GD
蛋白质环是一类新的不规则二级结构，是一段连续的多肽链，在三维空间中沿着“环状”路径行进;理想化环的主链类似于希腊语的ω。对已知结构的67种蛋白质进行了系统研究，揭示了270个Ω环。虽然这种环通常被认为是“无规卷曲”，但它们实际上是高度紧凑的亚结构，也可以是独立的折叠单元。环几乎总是位于蛋白质表面，在那里它们准备承担分子功能和生物识别的重要作用。它们经常被观察到是进化交换的模块，也是生物工程研究的天然候选者。
The protein loop, a novel category of nonregular secondary structure, is a segment of contiguous polypeptide chain that traces a "loop-shaped" path in three-dimensional space; the main chain of an idealized loop resembles a Greek omega (ω). A systematic study was made of 67 proteins of known structure revealing 270 omega loops. Although such loops are typically regarded as "random coil," they are, in fact, highly compact substructures and may also be independent folding units. Loops are almost invariably situated at the protein surface where they are poised to assume important roles in molecular function and biological recognition. They are often observed to be modules of evolutionary exchange and are also natural candidates for bioengineering studies.