Translocation (18;22)(q21;q11) in B-cell lymphomas: a report of 4 cases and review of the literature
Translocation (18;22)(q21;q11) in B-cell lymphomas: a report of 4 cases and review of the literature
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DOI：
10.1016/j.humpath.2008.04.007
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发表时间：
2008-11-01
期刊：
影响因子：
3.3
通讯作者：
Medeiros, L. Jeffrey
中科院分区：
文献类型：
--
作者：
Lin, Pei;Jetty, Rechna;Medeiros, L. Jeffrey
滤泡性淋巴瘤特征性地携带t（14;18）（q32;q21），其导致IGH-BCL-2融合。BCL-2基因与免疫球蛋白κ（2 p11）和λ（22 q11）轻链基因并列的变异易位是罕见的。我们报告4例与t（18;22）（q21;q11）相关的B细胞淋巴瘤/白血病。2例常规细胞遗传学检查仅发现t（18;22）（c21-q11）异常。3例为慢性淋巴细胞白血病，1例为滤泡性淋巴瘤。4例均用BCL-2断裂探针进行荧光原位杂交分析。BCL-2基因重排在所有病例中。3例使用细菌人工染色体探针跨越IG λ可变和恒定簇，显示免疫球蛋白λ轻链基因重排。基因使用MALT-1断裂探针，每个病例的MALT-1重排均为阴性。这些病例说明t（18;22）（q21;q11）在慢性淋巴细胞白血病中更常见，可能代表初始或继发遗传事件。(C)2008年爱思唯尔公司All rights reserved.
Follicular lymphomas characteristically carry t(14;18)(q32;q21) which results in IGH-BCL-2 fusion. Variant translocations that juxtapose the BCL-2 gene with the immunoglobulin kappa (2p11) and lambda (22q11) light chain genes are rare. We report 4 cases of B-cell lymphoma/leukemia associated with t(18;22)(q21;q11). The t(18;22)(c21-q11) was the sole aberration identified by conventional cytogenetics in 2 cases. Three cases were classified as chronic lymphocytic leukemia, and one as follicular lymphoma based oil morphology and immunophenotype. Fluorescence in situ hybridization analysis was performed oil all 4 cases using a BCL-2 breakapart probe. The BCL-2 gene was rearranged in all cases. Immunoglobulin lambda light chain gene rearrangement was shown in 3 cases using bacterial artificial chromosome probes spanning the variable and constant clusters of the IG lambda. gene. Each case was negative for MALT-I rearrangement using a MALT-1 breakapart probe. These cases illustrate that t(18;22)(q21;q11) is more commonly observed in chronic lymphocytic leukemia and may represent either an initial or secondary genetic event. (C) 2008 Elsevier Inc. All rights reserved.