Estrogen and α-fetoprotein levels in maternal and umbilical cord blood samples in relation to birth weight
Estrogen and α-fetoprotein levels in maternal and umbilical cord blood samples in relation to birth weight
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DOI：
10.1158/1055-9965.epi-06-0158
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发表时间：
2006-08-01
影响因子：
3.8
通讯作者：
Shimizu, Hiroyuki
中科院分区：
文献类型：
--
作者：
Nagata, Chisato;Iwasa, Shinichi;Shimizu, Hiroyuki
出生体重与随后患乳腺癌的风险有关。本研究调查了出生体重与妊娠雌激素和甲胎蛋白（AFP）之间的关系。研究人员测量了194名妇女在怀孕和分娩时的母体和脐带血样本中雌二醇、雌三醇和甲胎蛋白的浓度。在控制协变量后，出生体重与第29周（雌二醇：r = 0.16, P = 0.03；雌三醇：r = 0.29, P = 0.001）和分娩时（雌二醇：r = 0.20, P = 0.01；雌三醇：r = 0.41, P < 0.0001）母体血清雌二醇和雌三醇水平呈显著正相关。脐带雌三醇水平与出生体重呈中度但显著相关（r = 0.15, P = 0.049）。脐带血清雌二醇与新生儿出生体重无显著相关性。在任何妊娠周，出生体重与母体血清AFP均无显著相关性。脐带AFP与出生体重呈显著负相关（r = -0.16, P = 0.04）。脐带AFP与脐带雌二醇和雌三醇水平无关。数据表明，高出生体重的婴儿更多地接触雌三醇，而更少地接触甲胎蛋白。
Birth weight has been associated with a subsequent risk of breast cancer. The present study examined associations between birth weight and pregnancy estrogens and alpha-fetoprotein (AFP). The concentrations of estradiol, estriol, and AFP were measured in maternal and umbilical cord blood samples from 194 women during pregnancy and at birth. Birth weight was significantly positively correlated with maternal serum estradiol and estriol levels in the 29th week (estradiol: r = 0.16, P = 0.03; estriol: r = 0.29, P = 0.001) and at delivery (estradiol: r = 0.20, P = 0.01; estriol: r = 0.41, P < 0.0001) after controlling for covariates. The umbilical cord estriol level was moderately but significantly correlated with birth weight (r = 0.15, P = 0.049). There was no significant association between umbilical cord serum estradiol and birth weight. There was no significant association between birth weight and maternal serum AFP in any gestational week. Umbilical cord AFP was significantly inversely correlated with birth weight (r = -0.16, P = 0.04). Umbilical cord AFP was unrelated to cord levels of estradiol and estriol. The data suggested a greater exposure to estriol and a lower exposure to AFP among high birth weight babies.