Crosstalk between transcription and metabolism: how much enzyme is enough for a cell?
Crosstalk between transcription and metabolism: how much enzyme is enough for a cell?
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DOI：
10.1002/wsbm.1396
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发表时间：
2018-01-01
影响因子：
7.9
通讯作者：
Link, Hannes
中科院分区：
文献类型：
--
作者：
Donati, Stefano;Sander, Timur;Link, Hannes
细胞采用各种机制来动态控制酶的表达。一个重要的机制是转录和代谢之间的相互反馈或串扰。正如最近提出的那样，酶水平通常远远高于维持代谢通量的绝对需要。然而，考虑到高酶水平的潜在负担，细胞似乎可能控制酶表达以满足其他细胞目标。在这篇综述中，我们讨论了代谢和转录之间的串扰是否可以告知细胞多少酶是最佳的各种健身方面。为了理解通过串扰优化酶水平，应该解决两个主要问题。首先，代谢产物-蛋白质相互作用的映射对于更好地理解串扰的机理至关重要。其次，研究确定最佳酶水平的细胞目标可以揭示串扰的功能相关性。我们提出了最近的研究，接近这些问题，从实验转录和代谢数据，并从理论网络分析。WIREs Syst Biol Med 2018，10：e1396。土井：10.1002/wsbm.1396这篇文章分类下：生物机制>代谢实验室方法和技术>代谢组学生物机制>调控生物学
Cells employ various mechanisms for dynamic control of enzyme expression. An important mechanism is mutual feedbackor crosstalkbetween transcription and metabolism. As recently suggested, enzyme levels are often much higher than absolutely needed to maintain metabolic flux. However, given the potential burden of high enzyme levels it seems likely that cells control enzyme expression to meet other cellular objectives. In this review, we discuss whether crosstalk between metabolism and transcription could inform cells about how much enzyme is optimal for various fitness aspects. Two major problems should be addressed in order to understand optimization of enzyme levels by crosstalk. First, mapping of metabolite-protein interactions will be crucial to obtain a better mechanistic understanding of crosstalk. Second, investigating cellular objectives that define optimal enzyme levels can reveal the functional relevance of crosstalk. We present recent studies that approach these problems, drawing from experimental transcript and metabolite data, and from theoretical network analyses. WIREs Syst Biol Med 2018, 10:e1396. doi: 10.1002/wsbm.1396 This article is categorized under: Biological Mechanisms > Metabolism Laboratory Methods and Technologies > Metabolomics Biological Mechanisms > Regulatory Biology