A Formidable Foe Is Sabotaging Your Results: What You Should Know about Biofilms and Wound Healing.
A Formidable Foe Is Sabotaging Your Results: What You Should Know about Biofilms and Wound Healing.
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DOI：
10.1097/prs.0000000000003325
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发表时间：
2017-05
影响因子：
3.6
通讯作者：
Gordillo GM
中科院分区：
文献类型：
--
作者：
Barker JC;Khansa I;Gordillo GM
阅读本文后，参与者应该能够： 1. 描述与问题伤口相关的生物膜发病机制， 2. 了解问题伤口中涉及生物膜的临床前和临床证据， 3. 解释生物膜对问题伤口造成的诊断和治疗挑战， 4. 展示对旨在抵消这些过程的新兴策略的基本了解。生物膜代表了细菌的一种受保护的生长模式，使它们能够逃避标准诊断技术并避免被标准疗法根除。尽管最近才被发现，但生物膜已经存在了数千年，并且使医学的几乎各个方面变得复杂。生物膜通过允许细菌逃避免疫反应、延长炎症和禁用皮肤屏障功能来影响伤口愈合。重要的是要了解为什么尽管采用了最先进的治疗方法，问题伤口仍然存在，为什么它们难以准确诊断，以及为什么它们会复发。本文的目的是关注当前与问题伤口相关的知识差距，特别是生物膜感染。
After reading this article, the participant should be able to: 1. Describe biofilm pathogenesis as it relates to problem wounds, 2. Understand the pre-clinical and clinical evidence implicating biofilm in problem wounds, 3. Explain the diagnostic and treatment challenges that biofilms create for problem wounds, 4. Demonstrate a basic understanding of emerging strategies aimed at counteracting these processes. Biofilm represents a protected mode of growth for bacteria, allowing them to evade standard diagnostic techniques and avoid eradication by standard therapies. Though only recently discovered, biofilm has existed for millennia and complicates nearly every aspect of medicine. Biofilm impacts wound healing by allowing bacteria to evade immune responses, prolonging inflammation and disabling skin barrier function. It is important to understand why problem wounds persist despite state-of-the-art treatment, why they are difficult to accurately diagnose, and why they recur. The aim of this article is to focus on current gaps in knowledge related to problem wounds, specifically, biofilm infection.