Postprandial thermogenesis in obesity.
Postprandial thermogenesis in obesity.
复制标题
肥胖症的餐后生热作用。
DOI：
10.1042/cs0600519
复制
发表时间：
1981
期刊：
影响因子：
6
通讯作者：
B. Callingham
中科院分区：
文献类型：
--
作者：
P. Shetty;R. Jung;W. James;M. Barrand;B. Callingham
1.对瘦肉型、肥胖型和既往肥胖型女性在流食后的生热反应、血浆底物和激素的变化进行了检测。2.有肥胖家族史的受试者，无论是在肥胖期间接受测试，还是在减肥至正常体重后进行测试，都会产生发热反应，这只是瘦身组的一半。3.瘦体受试者对血糖和胰岛素的即刻反应较大，但循环底物的持续变化在三组中没有差异。餐后甲状腺激素浓度没有改变：静脉去甲肾上腺素水平仅在肥胖组升高。4.安静状态下餐后产热的差异将减少家族性肥胖者的能量需求，但他们的代谢率仍比瘦肉组高出近1MJ(240千卡)/天，因此必须存在额外的生热性缺陷，才能仅从代谢基础上解释家族性肥胖症。
1. The thermogenic response and changes in plasma substrates and hormones were tested after a liquid meal in lean, obese and formerly obese women. 2. Subjects with a family history of obesity tested either while obese or after slimming to a normal weight had a thermogenic response, which was only half that of the lean group. 3. The immediate response in plasma glucose and insulin was greater in the lean subjects, but the sustained changes in circulating substrates did not differ in the three groups. Thyroidal hormone concentrations did not alter postprandially: venous noradrenaline levels rose in the obese groups only. 4. The differences in postprandial thermogenesis at rest would reduce the energy requirements of subjects with familial obesity, but they still had a metabolic rate estimated to be nearly 1MJ (240 kcal)/day in excess of the lean group so additional thermogenic defects must exist for familial obesity to be explained solely on a metabolic basis.