Vanillic acid inhibits inflammatory mediators by suppressing NF-κB in lipopolysaccharide-stimulated mouse peritoneal macrophages
Vanillic acid inhibits inflammatory mediators by suppressing NF-κB in lipopolysaccharide-stimulated mouse peritoneal macrophages
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DOI：
10.3109/08923973.2010.547500
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发表时间：
2011-09-01
影响因子：
3.3
通讯作者：
Hong, Seung-Heon
中科院分区：
文献类型：
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作者：
Kim, Min-Cheol;Kim, Su-Jin;Hong, Seung-Heon
香草酸是一种苯甲酸衍生物，用作调味剂。它是香草醛的氧化形式。目前，香草酸发挥抗炎作用的机制还不完全清楚。在这项研究中，我们试图确定香草酸对脂多糖（LPS）诱导的小鼠腹腔巨噬细胞炎症反应的影响。我们的研究结果表明香草酸抑制脂多糖诱导的肿瘤坏死因子（TNF）-α和白细胞介素（IL）-6的产生。在炎症过程中，小鼠腹腔巨噬细胞内环氧合酶（考克斯）2和一氧化氮（NO）水平升高，香草酸可抑制考克斯2的升高和前列腺素E2和NO的产生，并抑制核因子-κ B（NF-κ B）和caspase-1的活化。这些结果为香草酸的药理作用提供了新的见解，并表明这种分子在治疗炎症性疾病中的潜在用途。
Vanillic acid is a benzoic acid derivative that is used as a flavoring agent. It is an oxidized form of vanillin. At present, the mechanisms by which vanillic acid exerts its anti-inflammatory effects are incompletely understood. In this study, we attempted to determine the effects of vanillic acid on lipopolysaccharide (LPS)-induced inflammatory responses in mouse peritoneal macrophages. Our findings indicate that vanillic acid inhibits LPS-induced production of tumor necrosis factor (TNF)-alpha and interleukin (IL)-6. During the inflammatory process, the levels of cyclooxygenase (COX)-2 and nitric oxide (NO) increased in mouse peritoneal macrophages, but vanillic acid suppressed both the enhanced levels of COX-2 and the production of prostaglandin E 2 and NO. Moreover, vanillic acid suppressed the activation of nuclear factor-kappa B (NF-kappa B) and caspase-1. These results provide novel insights into the pharmacological actions of vanillic acid and are indicative of the potential use of this molecule in the treatment of inflammatory diseases.