Multifunctional Polypyrrole-Coated Mesoporous TiO2 Nanocomposites for Photothermal, Sonodynamic, and Chemotherapeutic Treatments and Dual-Modal Ultrasound/Photoacoustic Imaging of Tumors
Multifunctional Polypyrrole-Coated Mesoporous TiO2 Nanocomposites for Photothermal, Sonodynamic, and Chemotherapeutic Treatments and Dual-Modal Ultrasound/Photoacoustic Imaging of Tumors
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用于肿瘤光热、声动力和化疗治疗以及双模态超声/光声成像的多功能聚吡咯涂层介孔二氧化钛纳米复合材料
DOI：
10.1002/adhm.201801254
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发表时间：
2019-05-01
影响因子：
10
通讯作者：
Zhang, Liangke
中科院分区：
文献类型：
--
作者：
He, Yue;Wan, Jingyuan;Zhang, Liangke
近年来，纳米二氧化钛已成为声动力疗法中理想的声敏剂，但载药能力差、构建合适的二氧化钛纳米颗粒的技术不足等缺点限制了其更广泛的应用。因此，本文将介孔纳米二氧化钛(MTiO2)S与光热材料聚吡咯(PPY)相结合，制备了多功能纳米复合材料，对肿瘤具有协同治疗作用。PPY包覆的介孔二氧化钛纳米复合材料(MTiO2PPYs)既可以作为药物载体，也可以作为超声激活的声敏剂和光热剂。此外，mTiO(2)@PPY有可能作为超声/光声(US/PA)成像造影剂。结果表明，mTiO2PPY具有良好的载药量和良好的光热转化能力。此外，细胞内活性氧的产生也得到了验证。对HepG2和4T1细胞的体外细胞实验表明，载和厚朴酚(HNK)的mTiO2PPY在激光和超声照射下具有良好的细胞毒性，动物实验进一步验证了这一结果。在体内外研究了mTiO(2)@PPY作为US和PA成像造影剂的能力。结果表明，mTiO(2)@PPY-HNK具有多种治疗作用和双峰成像特性，是一种具有广阔应用前景的新型纳米体系。
TiO2 nanoparticles have emerged as satisfactory sonosensitizers in sonodynamic therapy over the years, but shortcomings such as poor drug loading capability and inadequate techniques to construct suitable TiO2 nanoparticles, limit their broader applications. Hence, in this paper, versatile nanocomposites that combine mesoporous TiO2 nanoparticles (mTiO(2)s) with the promising photothermal material, polypyrrole (PPY) to exert synergistic therapeutic effects on tumors are fabricated. The PPY-coated mesoporous TiO2 nanocomposites (mTiO(2)@PPYs) act as drug delivery vehicles and ultrasonically activated sonosensitizers as well as photothermal agents. Besides, mTiO(2)@PPY may have potential as an ultrasound/photoacoustic (US/PA) imaging contrast agent. The mTiO(2)@PPY shows a favorable drug loading and good photothermal conversion ability. Moreover, intracellular reactive oxygen species generation is verified. The in vitro cell experiments on HepG2 and 4T1 cells demonstrate that honokiol (HNK)-loaded mTiO(2)@PPY has satisfactory cytotoxicity under laser and US irradiation, and the results are further validated by animal experiments. The ability of mTiO(2)@PPY as a contrast agent for US and PA imaging is investigated both in vitro and in vivo. The results indicate that mTiO(2)@PPY-HNK has multitherapeutic effects and bimodal imaging property, which shows great prospect as a novel nanosystem in antitumor applications.