Sox proteins: regulators of cell fate specification and differentiation
Sox proteins: regulators of cell fate specification and differentiation
复制标题
DOI：
10.1242/dev.091793
复制
发表时间：
2013-10-15
期刊：
影响因子：
4.6
通讯作者：
Kondoh, Hisato
中科院分区：
文献类型：
--
作者：
Kamachi, Yusuke;Kondoh, Hisato
Sox转录因子在发育过程中发挥着广泛的作用;然而，它们的通用功能具有相对简单的基础：Sox蛋白单独与DNA结合不会引起转录激活或抑制，但需要伴侣转录因子与DNA上的相邻位点结合。因此，Sox蛋白的活性取决于其伴侣因子的身份和与其结合的DNA序列的背景。在这本引物中，我们提供了一个机制的概述，如何Sox家族蛋白质的功能，作为一个范式的转录调控发展涉及多转录因子复合物，我们讨论了如何Sox因子，从而可以调节不同的过程中的发展。
Sox transcription factors play widespread roles during development; however, their versatile functions have a relatively simple basis: the binding of a Sox protein alone to DNA does not elicit transcriptional activation or repression, but requires binding of a partner transcription factor to an adjacent site on the DNA. Thus, the activity of a Sox protein is dependent upon the identity of its partner factor and the context of the DNA sequence to which it binds. In this Primer, we provide an mechanistic overview of how Sox family proteins function, as a paradigm for transcriptional regulation of development involving multi-transcription factor complexes, and we discuss how Sox factors can thus regulate diverse processes during development.