Asymmetric Phosphine-Catalyzed [4+1] Annulations of o-Quinone Methides with MBH Carbonates
Asymmetric Phosphine-Catalyzed [4+1] Annulations of o-Quinone Methides with MBH Carbonates
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不对称膦催化 [4 1] 邻醌甲基化物与 MBH 碳酸盐的环化
DOI：
10.1002/adsc.201801152
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发表时间：
2018
影响因子：
5.4
通讯作者：
Zhang Junliang
中科院分区：
文献类型：
--
作者：
Zhou Tao;Xia Tong;Liu Zhenli;Liu Lu;Zhang Junliang
手性二氢苯并呋喃单元经常存在于具有重要生物和药物活性的分子中。在此，我们提出了第一个不对称选择性的Morita-Baylis-Hillman碳酸酯与邻醌甲基化物（o-QMs）的[4+1]成环反应，该反应是在一种新设计的手性膦催化剂的催化下进行的。在温和、环境友好的条件下，以良好的产率和优异的对映选择性获得了多种多取代二氢苯并呋喃。
Chiral dihydrobenzofuran units are frequently present in molecules with significant biological and pharmaceutical activities. Herein, we present the first enantioselective formal [4+1] annulation of Morita‐Baylis‐Hillman carbonates witho‐quinone methides (o‐QMs) catalyzed by a newly designed chiral phosphine catalyst. Under the mild and eco‐friendly conditions, a wide range of polysubstituted dihydrobenzofurans were obtained in good yields with excellent enantioselectivities.