Dyskinesia is Closely Associated with Synchronization of Theta Oscillatory Activity Between the Substantia Nigra Pars Reticulata and Motor Cortex in the Off L-dopa State in Rats
Dyskinesia is Closely Associated with Synchronization of Theta Oscillatory Activity Between the Substantia Nigra Pars Reticulata and Motor Cortex in the Off L-dopa State in Rats
复制标题
运动障碍与大鼠左旋多巴状态下黑质网状部和运动皮层之间的 θ 振荡活动同步密切相关
DOI：
10.1007/s12264-020-00606-3
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发表时间：
2021-03-01
影响因子：
5.6
通讯作者：
Zhang, Wangming
中科院分区：
文献类型：
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作者：
Chen, Jiazhi;Wang, Qiang;Zhang, Wangming
在老年帕金森病患者和左旋多巴（L-dopa）诱导的运动障碍（LID）动物模型中，已经报道了基底神经节（BG）中过度的θ（θ）频率振荡和同步，特别是在停用左旋多巴（关闭左旋多巴状态）期间记录的θ振荡。为了深入了解这种活动的过程，我们探讨了LID中初级运动皮层（M1）振荡活动和BG输出之间的关系。我们记录了局部场电位在黑质网状部（SNr）和M1清醒，注意力不集中的休息大鼠之前和之后的L-多巴启动在假对照组，帕金森病模型，LID模型组。我们发现，慢性左旋多巴增加θ同步和信息流之间的SNr和M1在关闭左旋多巴状态LID大鼠，与SNr到M1流的方向性。与开启状态相比，关闭状态下的θ振荡活动（θ同步和信息流）与异常不自主运动的关系更密切。我们的研究结果表明，θ振荡在M1可能是随之而来的异常同步放电的BG和支持的概念，M1 θ振荡可能参与诱导运动障碍。
Excessive theta (theta) frequency oscillation and synchronization in the basal ganglia (BG) has been reported in elderly parkinsonian patients and animal models of levodopa (L-dopa)-induced dyskinesia (LID), particularly the theta oscillation recorded during periods when L-dopa is withdrawn (the off L-dopa state). To gain insight into processes underlying this activity, we explored the relationship between primary motor cortex (M1) oscillatory activity and BG output in LID. We recorded local field potentials in the substantia nigra pars reticulata (SNr) and M1 of awake, inattentive resting rats before and after L-dopa priming in Sham control, Parkinson disease model, and LID model groups. We found that chronic L-dopa increased theta synchronization and information flow between the SNr and M1 in off L-dopa state LID rats, with a SNr-to-M1 flow directionality. Compared with the on state, theta oscillational activity (theta synchronization and information flow) during the off state were more closely associated with abnormal involuntary movements. Our findings indicate that theta oscillation in M1 may be consequent to abnormal synchronous discharges in the BG and support the notion that M1 theta oscillation may participate in the induction of dyskinesia.