Tardive dyskinesia: Possible involvement of free radicals and treatment with vitamin E
Tardive dyskinesia: Possible involvement of free radicals and treatment with vitamin E
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DOI：
10.1093/oxfordjournals.schbul.a033414
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发表时间：
1999-01-01
影响因子：
6.6
通讯作者：
Wyatt, RJ
中科院分区：
文献类型：
--
作者：
Elkashef, AM;Wyatt, RJ
十年前，为了解释迟发性运动障碍（TD）而提出的一个假说表明，抗精神病药物治疗后会产生自由基。从那时起，许多临床前和临床研究都调查了这种可能性。这些研究表明，自由基可能与 TD 的发病机制有关，而维生素 E 可能对其治疗有效。
A decade ago a hypothesis introduced to explain tardive dyskinesia (TD) implicated free radicals generated secondary to neuroleptic treatment. Since then many preclinical and clinical studies have investigated this possibility. These studies suggest that free radicals are probably involved in the pathogenesis of TD and that vitamin E could be efficacious in its treatment.