Evaluating change in health-related quality of life in adult rhinitis: responsiveness of the Rhinosinusitis Disability Index.
Evaluating change in health-related quality of life in adult rhinitis: responsiveness of the Rhinosinusitis Disability Index.
复制标题
DOI：
10.1186/1477-7525-3-68
复制
发表时间：
2005-11-08
影响因子：
3.6
通讯作者：
Blanc, Paul D
中科院分区：
文献类型：
--
作者：
Chen, Hubert;Katz, Patricia P;Blanc, Paul D
背景：鼻窦炎残疾指数(RSDI)是鼻炎患者健康相关生活质量(HRQL)的有效量度。RSDI对健康状况随时间的变化的反应还没有被描述。方法：我们研究了通过全国电话调查确诊为鼻炎的医生自我报告的成年人。使用RSDI在基线和24个月时评估HRQL。在每次访谈时，还评估了症状严重程度、身体健康状况(SF-12 PCS)、心理情绪(CES-D)和对症状的控制感。此外，我们还确定了与鼻炎有关的特定健康后果，包括限制活动的天数、工作效率、就医次数和药物费用。结果：在基线采访的109名受试者中，69人(63%)在24个月后再次接受采访。在13名(19%)受试者中，RSDI得分提高了=0.5，17名(25%)受试者的RSDI得分恶化。随着时间的推移，RSDI的变化与症状严重程度(r=0.38，p=0.001)、身体健康(r=-0.39，p=0.001)、情绪(r=0.37，p=0.002)和对症状的控制感(r=-0.37，p=0.002)的变化相关。在调整了基线健康状况的多变量分析中，RSDI的改善与更少的限制活动(p=0.01)、更高的工作效率(p=0.03)和更低的药物成本(p=0.05)相关，但与从基线到医生就诊次数的变化(p=0.45)无关。结论：RSDI对健康状况的变化做出反应，并预测鼻炎特有的健康结果。
BACKGROUND: The Rhinosinusitis Disability Index (RSDI) is a validated measure of health-related quality of life (HRQL) in rhinitis. Responsiveness of the RSDI to changes in health status over time has not been described.METHODS: We studied adults with a self-reported physician diagnosis of rhinitis identified through a national telephone survey. HRQL was assessed at baseline and at 24 months using the RSDI. Symptom severity, physical health status (SF-12 PCS), psychological mood (CES-D), and perceived control of symptoms were also assessed at the time of each interview. In addition, we ascertained specific health outcomes attributed to rhinitis, including days of restricted activity, job effectiveness, number of physician visits, and medication costs.RESULTS: Of 109 subjects interviewed at baseline, 69 (63%) were re-interviewed 24 months later. RSDI scores improved by = 0.5 standardized response mean in 13 (19%) subjects and worsened in 17 (25%). Change in the RSDI over time correlated with changes in symptom severity (r = 0.38, p = 0.001), physical health (r = -0.39, p = 0.001), mood (r = 0.37, p = 0.002) and perceived control of symptoms (r = -0.37, p = 0.01). In multivariate analyses adjusted for baseline health status, improvement in RSDI was associated with less restricted activity (p = 0.01), increased job effectiveness (p = 0.03), and decreased medication costs (p = 0.05), but was not associated with change in the number of physician visits from baseline (p = 0.45).CONCLUSION: The RSDI is responsive to changes in health status and predicts rhinitis-specific health outcomes.