Photoreceptor Regulation of Spatial Visual Behavior
Photoreceptor Regulation of Spatial Visual Behavior
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DOI：
10.1167/iovs.14-15644
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发表时间：
2015-03-01
影响因子：
4.4
通讯作者：
Prusky, Glen T.
中科院分区：
文献类型：
--
作者：
Alam, Nazia M.;Altimus, Cara M.;Prusky, Glen T.
目的。为了更好地了解光感受器及其电路如何支持依赖于亮度的空间视觉行为。方法：在确定的光感受器活动遗传改变的小鼠中，测量了用于视动跟踪的光栅阈值。结果：表征了使视锥和视杆介导的行为的亮度条件，以及视杆和视锥功能重叠的亮度范围。AII无长突通路支持低分辨率和高对比度功能，杆-锥通路支持高分辨率和低对比度功能。仅视杆细胞也被证明能够驱动锥体样空间视觉功能，但仅当视锥细胞被遗传地维持在生理黑暗状态时。结论：这项研究定义了亮度信号如何驱动视锥细胞和视锥细胞介导的空间视觉行为，并揭示了视杆细胞依赖于视锥细胞和视杆细胞系统之间的相互作用的新的和意想不到的贡献。
PURPOSE. To better understand how photoreceptors and their circuits support luminance-dependent spatial visual behavior.METHODS. Grating thresholds for optokinetic tracking were measured under defined luminance conditions in mice with genetic alterations of photoreceptor activity.RESULTS. The luminance conditions that enable cone- and rod-mediated behavior, and the luminance range over which rod and cone functions overlap, were characterized. The AII amacrine pathway was found to support low-resolution and high-contrast function, with the rod-cone pathway supporting high-resolution and low-contrast function. Rods alone were also shown to be capable of driving cone- like spatial visual function, but only when cones were genetically maintained in a physiological dark state.CONCLUSIONS. The study defined how luminance signals drive rod- and cone-mediated spatial visual behavior and revealed new and unexpected contributions for rods that depend on an interaction between cone and rod systems.