Age and Education Effects on Relationships of Cognitive Test Scores With Brain Structure in Demographically Diverse Older Persons
Age and Education Effects on Relationships of Cognitive Test Scores With Brain Structure in Demographically Diverse Older Persons
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DOI：
10.1037/a0013421
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发表时间：
2009-03-01
影响因子：
3.7
通讯作者：
DeCarli, Charles
中科院分区：
文献类型：
--
作者：
Mungas, Dan;Reed, Bruce R.;DeCarli, Charles
这项研究探讨了年龄和教育如何影响神经心理学测试分数和大脑结构之间的关系，在人口统计学上不同的老年人，从正常认知到痴呆症。351名非裔美国人，410名西班牙裔美国人和458名白人接受了神经心理学测试。对79名非洲裔美国人、102名西班牙裔美国人和134名白人进行了全脑、白色高信号和海马体的体积磁共振成像（MRI）测量。作者使用潜变量模型来研究年龄，教育和脑容量对测试成绩的影响，并确定脑容量在未调整和年龄和教育调整的分数中解释了多少差异。年龄调整导致较弱的关系，测试分数与MRI变量;调整种族产生更强的关系。在合并样本和西班牙裔中，教育调整增加了与MRI变量的关系，在白人中没有差异，但在非洲裔美国人中减少了一些关联。结果表明，人口统计学调整是有益的，当人口统计学变量与测试成绩独立的大脑结构的措施，但调整有负面后果时，人口统计学特征的影响是由大脑结构介导的。
This study examined how age and education influence the relationship between neuropsychological test scores and brain structure in demographically diverse older adults spanning the range from normal cognition to dementia. A sample of 351 African Americans, 410 Hispanics, and 458 Whites underwent neuropsychological testing. Volumetric magnetic resonance imaging (MRI) measures of total brain, white matter hyperintensity, and hippocampus were available for 79 African Americans, 102 Hispanics, and 134 Whites. The authors used latent variable modeling to examine effects of age, education, and brain volumes on test scores and determine how much variance brain volumes explained in unadjusted and age- and education-adjusted scores. Age adjustment resulted in weaker relationships of test scores with MRI variables; adjustment for ethnicity yielded stronger relationships. Education adjustment increased relationships with MRI variables in the combined sample and Hispanics, made no difference in Whites, but decreased some associations in African Americans. Results suggest that demographic adjustment is beneficial when demographic variables are strongly related to test scores independent of measures of brain structure, but adjustment has negative consequences when effects of demographic characteristics are mediated by brain structure.