Overview of sarcomas in the adolescent and young adult population
Overview of sarcomas in the adolescent and young adult population
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DOI：
10.1097/01.mph.0000161762.53175.e4
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发表时间：
2005-04-01
影响因子：
1.2
通讯作者：
Herzog, CE
中科院分区：
文献类型：
--
作者：
Herzog, CE
根据美国国家癌症研究所（SEER）项目的监测、流行病学和最终结果部分的数据，软组织和骨肉瘤约占美国每年新诊断的所有恶性肿瘤的1%。然而，有许多不同的组织学类型，任何特定类型的肉瘤都是极其罕见的。由于报道的数据有限，很难根据年龄和类型确定肉瘤的发病率。SEER项目收集有关年龄的数据，但只有有限的组织学数据，而大多数文献报道的系列包括成人或儿科患者，但很少两者兼有。为了估计青少年和年轻人中不同肉瘤的频率和绝对数量，德克萨斯大学安德森癌症中心（MDACC）的肿瘤登记处查询了1990年至2003年的所有软组织肉瘤和1990年至2002年的所有骨肉瘤。基于这个问题，肉瘤的概述，主要发生在青少年和年轻成人（AYA）人口提出。这些肉瘤包括横纹肌肉瘤、滑膜肉瘤、神经源性肉瘤、上皮样肉瘤、肺泡软组织肉瘤、尤文氏肉瘤和骨肉瘤。利用MDACC数据库中确定的每种组织学类型的发生率百分比，以及总体肉瘤发病率的SEER估计，对2004年AYA人群中主要组织学类型的新病例数量进行了估计。同时回顾了在AYA人群中出现的肉瘤中经常发生的染色体易位。
Based on the data of the Surveillance, Epidemiology and End Results Section of the National Cancer Institute (SEER) program, soft tissue and bone sarcomas account for about 1% of all new malignancies diagnosed in the United States each year. However, there are numerous different histologic types, and any given type of sarcoma is extremely rare. Determining the incidence of sarcomas by age and type is difficult due to the limited data reported. The SEER program collects data regarding age but only limited data on histology, while most series reported in the literature include either adults or pediatric patients, but rarely both. In an effort to estimate the frequency and absolute numbers of different sarcomas in the adolescent and young adult population, the University of Texas M. D. Anderson Cancer Center (MDACC) tumor registry was queried for all soft tissue sarcomas from 1990 through 2003, and all bone sarcomas from 1990 through 2002. Based on this query, an overview of sarcomas that occur predominantly in the adolescent and young adult (AYA) population is presented. These sarcomas include rhabdomyosarcoma, synovial sarcoma, neurogenic sarcoma, epithelioid sarcomas, alveolar soft parts sarcoma, Ewing sarcoma, and osteosarcoma. Using the percentages for occurrence of each histologic type determined from the MDACC database, and the SEER estimate of overall sarcoma incidence, an estimate of the number of new cases in 2004 for the predominant histologic types occurring in the AYA population are presented. Also reviewed are the chromosomal translocations that occur frequently in sarcomas presenting in the AYA population.