Nitro-fatty acid formation and metabolism.

Nitro-fatty acid formation and metabolism.
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DOI:
10.1016/j.niox.2018.07.003
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发表时间:
2018-09-01
期刊:
Nitric oxide : biology and chemistry
影响因子:
--
通讯作者:
Gelhaus Wendell S
Gelhaus Wendell S
中科院分区:
其他
文献类型:
--
作者:
Buchan GJ;Bonacci G;Fazzari M;Salvatore SR;Gelhaus Wendell S

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硝基脂肪酸(NO2-FA)是氧化还原信号通路的多效性调节剂。它们对炎症信号传导的作用已经在细胞、动物和临床模型中进行了非常详细的研究,主要使用外源性给予的硝基油酸。虽然我们知道很多关于它们的信号,内源性NO2-FA的形成和代谢是相对未开发的。本次审查将涵盖目前已知的关于拟议的形成机制,内源性NO2-FA水平的饮食调节,NO2 FA和相应的代谢产物的代谢和检测途径。
Nitro-fatty acids (NO2-FA) are pleiotropic modulators of redox signaling pathways. Their effects on inflammatory signaling have been studied in great detail in cell, animal and clinical models primarily using exogenously administered nitro-oleic acid. While we know a great deal about their signaling, endogenous NO2-FA formation and metabolism is relatively unexplored. This review will cover what is currently known regarding proposed mechanisms of formation, dietary modulation of endogenous NO2-FA levels, and pathways of metabolism and detection of NO2FA and corresponding metabolites.
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