Nitro-fatty acid formation and metabolism.
Nitro-fatty acid formation and metabolism.
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DOI:
10.1016/j.niox.2018.07.003
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发表时间:
2018-09-01
期刊:
影响因子:
--
通讯作者:
Gelhaus Wendell S
中科院分区:
文献类型:
--
作者:
Buchan GJ;Bonacci G;Fazzari M;Salvatore SR;Gelhaus Wendell S
Nitro-fatty acids (NO2-FA) are pleiotropic modulators of redox signaling pathways. Their effects on inflammatory signaling have been studied in great detail in cell, animal and clinical models primarily using exogenously administered nitro-oleic acid. While we know a great deal about their signaling, endogenous NO2-FA formation and metabolism is relatively unexplored. This review will cover what is currently known regarding proposed mechanisms of formation, dietary modulation of endogenous NO2-FA levels, and pathways of metabolism and detection of NO2FA and corresponding metabolites.
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