Randomized, double-blind, sham-controlled evaluation of the effect of functional continuous magnetic stimulation in patients with urgency incontinence
Randomized, double-blind, sham-controlled evaluation of the effect of functional continuous magnetic stimulation in patients with urgency incontinence
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DOI：
10.1002/nau.20423
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发表时间：
2007-01-01
影响因子：
2
通讯作者：
Ohkawa, Hiromi
中科院分区：
文献类型：
--
作者：
Suzuki, Tsuneki;Yasuda, Kosaku;Ohkawa, Hiromi
目的：以随机、假手术对照的方式评估功能性连续磁刺激 (FCMS) 对急迫性尿失禁的影响。方法：39 名对盆底肌肉训练 (PFMT) 无效的急迫性尿失禁患者，其中 16 名男性和 23 名女性（年龄 66.0 +/- 16.5 岁）被随机分配至执行 10 周积极治疗、随后 4 周不治疗间隔、然后 10 周假治疗的治疗方案（A-S，n = 20）或执行首先进行假治疗，然后进行为期 10 周的积极治疗（S-A，n = 19）。结果：10周时，前组每周漏尿次数、国际失禁问卷咨询简表（ICIQ-SF）总分和最大膀胱测压能力（MCC）均较初始水平显着改善（分别为P < 0.001、P < 0.001和P = 0.003），而后一组则无显着改善。 A-S 组有 4 例（20.0%）患者治愈，而 S-A 组无患者治愈。在A-S方案结束时（研究24周），与初始水平相比，积极治疗的效果仍保持在显着改善的水平。 S-A 计划结束时，与初始水平和 10 周水平相比（分别为 P < 0.001 和 P = 0.049），每周泄漏次数以及 ICIQ-SF 总分（分别为 P = 0.001 和 P = 0.006）均显着改善。 MCC 较初始水平显着增加 (P = 0.030)。结论：在这个小患者组中，与假刺激相比，磁刺激对急迫性尿失禁有效。
Aims: To evaluate the effect of functional continuous magnetic stimulation (FCMS) on urgency incontinence in randomized, sham-controlled manner. Methods: Thirty-nine patients with urgency incontinence, 16 males and 23 females (aged 66.0 +/- 16.5 years), who were refractory to pelvic floor muscle training (PFMT), were randomly assigned either to the treatment schedule performing 10-week active treatment, followed by 4-week non-treatment interval and then by 10-week sham treatment (A-S, n = 20) or to that performing the sham treatment first followed by 10-week active treatment (S-A, n = 19). Results: At 10 weeks, the number of leaks/week, the total score of the International Consultation on Incontinence-Questionnaire: Short Form (ICIQ-SF), and maximum cystometric capacity (MCC) were significantly improved as compared with the initial levels (P < 0.001, P < 0.001, and P = 0.003, respectively) in the former group, but not in the latter group. Four (20.0%) patients were cured in the A-S group, while no patient was cured in the S-A group. At the end of the A-S schedule (24 weeks of study), the effect of the active treatment was still maintained at a significantly improved level, as compared with the initial level. At the end of the S-A schedule, the number of leaks/week was significantly improved as compared with the initial level and with its 10-week level (P < 0.001 and P = 0.049, respectively), as well as ICIQ-SF total score (P = 0.001 and P = 0.006, respectively). MCC significantly increased from its initial level (P = 0.030). Conclusion: Magnetic stimulation was effective on urgency incontinence in comparison to sham stimulation in this small patient group.