Berkeley Phylogenomics Group web servers: resources for structural phylogenomic analysis.
Berkeley Phylogenomics Group web servers: resources for structural phylogenomic analysis.
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伯克利系统基因组学组Web服务器：结构性系统基因分析的资源。
DOI：
10.1093/nar/gkm325
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发表时间：
2007-07
影响因子：
14.9
通讯作者：
Sjolander, Kimmen
中科院分区：
文献类型：
--
作者：
Glanville, Jake Gunn;Kirshner, Dan;Krishnamurthy, Nandini;Sjolander, Kimmen
系统基因分析解决了基于注释转移的功能预测的局限性，并已证明可以在蛋白质分子功能的预测中具有最高的准确性。伯克利系统基因组学小组提供了一系列用于系统基因分析的网络服务器：使用系统基因类百科全书对预计家族和亚家族的序列分类，蛋白质的花功率聚类，共享同一领域的蛋白建筑和Sciphy亚家族识别。 Thylobuilder Web服务器提供了一个集成的系统基因组管道，从用户提供的蛋白质序列开始，继续进行同源物识别，多重比对，系统发育树的构建，下属识别和结构预测。伯克利系统组学组资源可在http://pholyogenomics.berkeley.edu上获得。
Phylogenomic analysis addresses the limitations of function prediction based on annotation transfer, and has been shown to enable the highest accuracy in prediction of protein molecular function. The Berkeley Phylogenomics Group provides a series of web servers for phylogenomic analysis: classification of sequences to pre-computed families and subfamilies using the PhyloFacts Phylogenomic Encyclopedia, FlowerPower clustering of proteins sharing the same domain architecture, MUSCLE multiple sequence alignment, SATCHMO simultaneous alignment and tree construction and SCI-PHY subfamily identification. The PhyloBuilder web server provides an integrated phylogenomic pipeline starting with a user-supplied protein sequence, proceeding to homolog identification, multiple alignment, phylogenetic tree construction, subfamily identification and structure prediction. The Berkeley Phylogenomics Group resources are available at http://phylogenomics.berkeley.edu.