Does dark adaptation exacerbate diabetic retinopathy? Evidence and a linking hypothesis
Does dark adaptation exacerbate diabetic retinopathy? Evidence and a linking hypothesis
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DOI：
10.1016/s0042-6989(98)00004-2
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发表时间：
1998-06-01
期刊：
影响因子：
1.8
通讯作者：
Tsang, Y
中科院分区：
文献类型：
--
作者：
Arden, GB;Wolf, JE;Tsang, Y
本文综述了糖尿病患者眼底发生任何变化之前，血流、ERG和视觉功能发生变化的证据。在色觉和对比敏感度的情况下，这些变化通过呼吸氧气而部分逆转，因此是视网膜缺氧的结果。也有其他证据表明，缺氧是糖尿病视网膜病变（DR）发展的主要因素。因此，在患有早期视网膜病变但明视正常的糖尿病患者中，暗适应可能出现功能障碍，因为在这种情况下，如Linsenmeier及其同事所示，已经很低的视网膜PO显著降低。这一假设已经过检验，并得到了与假设一致的结果（与一些较早的报告一致）。这一发现早期DR的意义进行了讨论，并提出了一种机制，即在暗适应过程中长时间的缺氧可能会产生视网膜毛细血管的变化。这样的时期每天晚上都会发生，消除糖尿病患者的这种情况可能是治疗性的。(C)1998爱思唯尔科技有限公司版权所有。
The paper reviews evidence that before any change in diabetics' fundi, changes occur to blood flow, ERG and visual functions. In the case of colour vision and contrast sensitivity, the changes are partially reversed by breathing oxygen, and therefore are the result of retinal hypoxia. There are also other evidences that hypoxia is a major factor in the development of diabetic retinopathy (DR). Therefore in diabetics with early retinopathy, but normal photopic vision, functional disturbance might appear in dark adaptation, since in such circumstances, las shown by Linsenmeier and his colleagues) the already low retinal PO, markedly decreases. This hypothesis has been tested and results consistent with the hypothesis land with a number of older reports) have been obtained. The significance of this finding to early DR is discussed, and a mechanism suggested whereby prolonged periods of hypoxia during dark adaptation could generate changes in retinal capillaries. Such periods occur each night, and their elimination in diabetics could be therapeutic. (C) 1998 Elsevier Science Ltd. All rights reserved.