The Representation of S-Cone Signals in Primary Visual Cortex
The Representation of S-Cone Signals in Primary Visual Cortex
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DOI：
10.1523/jneurosci.1428-10.2010
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发表时间：
2010-08-04
影响因子：
5.3
通讯作者：
Fitzpatrick, David
中科院分区：
文献类型：
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作者：
Johnson, Elizabeth N.;Van Hooser, Stephen D.;Fitzpatrick, David
最近对灵长类初级视皮层（V1）中波长敏感和长波长敏感的视锥反应的研究挑战了颜色和形状由不同的神经元群体代表的观点。单个V1神经元表现出颜色和形式处理的特点（视锥细胞和方向选择性），许多显示锥相互作用，不适合经典的彩色/无色分类。短波长敏感（S）锥响应的比较分析尚未实现，是相当大的兴趣，因为S-锥是原始哺乳动物的染色质通路的基础。本研究利用树鼩的内源性和双光子成像技术，研究了V1层2/3神经元对S锥刺激的反应特性。这些反应是方向选择性的，表现出独特的时空特性，并反映了通过对手，求和和中间配置的S-锥输入的整合。我们的观察结果支持一个共同的框架表示的视锥细胞信号在V1，一个赋予方向选择性神经元的范围内的彩色，无色，和混合响应特性。
Recent studies of middle-wavelength-sensitive and long-wavelength-sensitive cone responses in primate primary visual cortex (V1) have challenged the view that color and form are represented by distinct neuronal populations. Individual V1 neurons exhibit hallmarks of both color and form processing (cone opponency and orientation selectivity), and many display cone interactions that do not fit classic chromatic/achromatic classifications. Comparable analysis of short-wavelength-sensitive (S) cone responses has yet to be achieved and is of considerable interest because S-cones are the basis for the primordial mammalian chromatic pathway. Using intrinsic and two-photon imaging techniques in the tree shrew, we assessed the properties of V1 layer 2/3 neurons responsive to S-cone stimulation. These responses were orientation selective, exhibited distinct spatiotemporal properties, and reflected integration of S-cone inputs via opponent, summing, and intermediate configurations. Our observations support a common framework for the representation of cone signals in V1, one that endows orientation-selective neurons with a range of chromatic, achromatic, and mixed response properties.