Sipunculan ParaHox genes
Sipunculan ParaHox genes
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DOI：
10.1046/j.1525-142x.2001.003004263.x
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发表时间：
2001-07-01
影响因子：
2.9
通讯作者：
Holland, PWH
中科院分区：
文献类型：
--
作者：
Ferrier, DEK;Holland, PWH
随着文昌鱼(Cephalochordata；Branchiostoma floridae)中ParaHox基因簇的发现，我们对Hox基因簇的起源和进化的看法发生了变化(Brooke等人。1998年)。ParaHox基因簇包含三个同源盒基因(GSX、Xlox、CDX)，推测为Hox基因簇的一个平行序列(进化姐妹)。如果这一推论是正确的，那么携带HOX基因的动物也应该拥有ParaHox基因。然而，矛盾的是，到目前为止，只有后口动物被证明包含所有三个ParaHox基因。在这里，我们报告了所有三个ParaHox基因的克隆，每个基因来自于Sipuncula门中的两个物种。这是首次在原生动物基因组中证明了所有三个ParaHox基因，并证实了原口动物和后口动物的共同祖先拥有所有三个ParaHox基因。此外，这意味着ParaHox基因在原口和后口都具有足够的功能重要性，因此它们在这两个双边分支中都是保守的。
Our perspective on the origin and evolution of the Hox gene cluster changed with the discovery of the ParaHox gene cluster in amphioxus (Cephalochordata; Branchiostoma floridae) (Brooke et al. 1998). The ParaHox gene cluster contains three homeobox genes (Gsx, Xlox, Cdx) and is deduced to be a paralogue (evolutionary sister) of the Hox gene cluster. If this deduction is correct, animals with Hox genes should also possess ParaHox genes. Paradoxically, however, only deuterostome animals have thus far been shown to contain all three ParaHox genes. Here we report the cloning of all three ParaHox genes from each of two species within the phylum Sipuncula. This is the first demonstration of all three ParaHox genes in the genome of a protostome animal and confirms that the common ancestor of protostomes and deuterostomes possessed all three ParaHox genes. Furthermore, it implies that the ParaHox genes are of sufficient functional importance in both protostomes and deuterostomes that they have all been conserved in both of these bilaterian clades.