SUPPRESSION BY HEPARIN OF SMOOTH-MUSCLE CELL-PROLIFERATION IN INJURED ARTERIES
SUPPRESSION BY HEPARIN OF SMOOTH-MUSCLE CELL-PROLIFERATION IN INJURED ARTERIES
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DOI：
10.1038/265625a0
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发表时间：
1977-01-01
期刊：
影响因子：
64.8
通讯作者：
KARNOWSKY, MJ
中科院分区：
文献类型：
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作者：
CLOWES, AW;KARNOWSKY, MJ
动脉内皮损伤后，内膜平滑肌细胞（SMC）增殖在愈合的早期阶段占主导地位1 -6;目前尚不清楚是什么生长因子导致了静止细胞的有丝分裂活动。血小板因子、胰岛素和脂蛋白7 - 11可促进SMC在体外的生长，根据一些报道，各种抗血小板药物可抑制SMC在体内的生长。Harkeret等6报道了用双嘧达莫治疗同型半胱氨酸血症狒狒的肌内膜增厚减少，Friedmanet等11和Mooreet等12报道了注射抗血小板血清的兔的受损动脉中SMC增殖受到抑制。然而，在给予各种抗血小板药物的大鼠的损伤颈动脉中，内膜增厚并没有减少13。由于凝血系统与动脉损伤密不可分，并且凝血酶用于产生血小板生长因子9，其本身可能是一种促分裂素14，15，我们推测肝素可能抑制肌内膜增厚。我们在这里报告使用肝素抑制动脉内皮损伤的大鼠模型中的内膜SMC增生，并提出肝素效应的可能机制。
INTIMAL smooth muscle cell (SMC) proliferation dominates the early phase of healing after arterial endothelial injury1–6; what growth factors are responsible for this mitotic activity of an otherwise quiescent cell is not known. SMC growthin vitrois enhanced by platelet factors, insulin and lipoproteins7–11and, according to some reports, can be diminishedin vivowith various antiplatelet agents. Harkeret al.6have reported decreased myointimal thickening in homocystinaemic baboons treated with dipyridamole, and Friedmanet al.11and Mooreet al.12have reported suppression of SMC proliferation in the injured arteries of rabbits injected with anti-platelet serum. Intimal thickening was not diminished, however, in the injured carotid arteries of rats given various anti-platelet drugs13. Because the clotting system is inextricably linked to arterial injury and because thrombin is used to generate the platelet growth factor9and may itself be a mitogen14,15, we speculated that heparin might inhibit myointimal thickening. We report here the use of heparin to suppress intimal SMC hyperplasia in a rat model of arterial endothelial injury and suggest possible mechanisms for the heparin effect.