STUDIES ON EXPERIMENTAL ALLERGIC (ISOIMMUNE) LABYRINTHITIS IN GUINEA PIGS.
STUDIES ON EXPERIMENTAL ALLERGIC (ISOIMMUNE) LABYRINTHITIS IN GUINEA PIGS.
复制标题
豚鼠实验性过敏（等免疫）迷路炎的研究。
DOI：
10.3109/00016486409121360
复制
发表时间：
1964
影响因子：
1.4
通讯作者：
S. Yukihiro
中科院分区：
文献类型：
--
作者：
T. Yoshihiko;S. Yukihiro
通过注射经弗氏佐剂乳化的豚鼠耳蜗，大多数豚鼠可引起耳蜗组织的声学和组织学紊乱，这被解释为对耳蜗组织的等免疫，尽管抗耳蜗抗体检测失败。单独注射佐剂未见阳性反应。主要组织学改变为螺旋神经节和血管纹。部分动物中耳膜出血，耳廓器官解体。这些变化通常与声学阈值的变化相对应。因此，有可能由于自身免疫反应，一只耳朵的内耳疾病会影响到另一只耳朵。
By injection of guinea pig cochlea emulsified with Freund's adjuvant, it was possible to induce in the majority of guinea pigs the acoustical and histological disturbances which were interpreted as an isoimmunization to cochlea tissue, although the detection of anticochlea antibody failed. No positive reaction occurred when adjuvant alone was injected. The main histological changes were found in the spiral ganglion and stria vascularis. In some animals, hemorrhage in the scala tympani and disintegration of the organ of Corti were observed. These changes generally corresponded to the acoustical threshold shifts. Thus there may be possibilities that the inner ear disease of one ear could affect the opposite ear as the result of an autoimmune reaction.