A novel low-friction surface for biomedical applications: modification of poly(dimethylsiloxane) (PDMS) with polyethylene glycol(PEG)-DOPA-lysine.
A novel low-friction surface for biomedical applications: modification of poly(dimethylsiloxane) (PDMS) with polyethylene glycol(PEG)-DOPA-lysine.
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DOI：
10.1002/jbm.a.32141
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发表时间：
2009-09-01
影响因子：
4.9
通讯作者：
Spencer, Nicholas D.
中科院分区：
文献类型：
--
作者：
Chawla, Kanika;Lee, Seunghwan;Lee, Bruce P.;Dalsin, Jeffrey L.;Messersmith, Phillip B.;Spencer, Nicholas D.
水性生物相容性摩擦系统是各种组织接触医疗器械所需要的。贻贝粘附蛋白的 L-3,4-二羟基苯丙氨酸 (DOPA) 和赖氨酸 (K) 肽模拟物与表面强烈相互作用，可用于摩擦系统中润滑聚合物的表面附着。在这里，我们描述了用 PEG-DOPA-K 改性后聚（二甲基硅氧烷）（PDMS）表面润滑性能的显着改善。通过光学和原子力显微镜、接触角、PM-IRRAS 和 X 射线光电子能谱对表面进行表征。经过 200 次旋转（长度约为 8m）的测试，此类表面与裸 PDMS (0.98±0.02) 相比保持极低的摩擦系数 (μ) (0.03±0.00)。这些结果表明 PEG-DOPA-K 在器件表面改性方面的潜在应用。在相对较长的长度尺度和一定范围的滑动速度下，可以保持极低的μ值，无需基材预活化，并且水溶液中不存在过量聚合物。这些结果仅在 DOPA 与赖氨酸结合时获得（PEG-DOPA 修饰对 μ 没有影响），表明赖氨酸在降低摩擦系数方面发挥着关键作用。
Aqueous biocompatible tribosystems are desirable for a variety of tissue-contacting medical devices. L-3,4-dihydroxyphenylalanine (DOPA) and lysine (K) peptide mimics of mussel adhesive proteins strongly interact with surfaces and may be useful for surface attachment of lubricating polymers in tribosystems. Here, we describe a significant improvement in lubrication properties of poly(dimethylsiloxane) (PDMS) surfaces when modified with PEG-DOPA-K. Surfaces were characterized by optical and atomic force microscopy, contact angle, PM-IRRAS, and X-ray photoelectron spectroscopy. Such surfaces, tested over the course of 200 rotations (~8m in length), maintained an extremely low friction coefficient (μ) (0.03±0.00) compared to bare PDMS (0.98±0.02). These results indicate the potential applications of PEG-DOPA-K for the modification of device surfaces. Extremely low μ values were maintained over relatively long length scales and a range of sliding speeds without the need for substrate pre-activation and in the absence of excess polymer in aqueous solution. These results were only obtained when DOPA was bound to lysine (modification with PEG-DOPA did not have an effect on μ) suggesting the critical role of lysine in obtaining a lowered friction coefficient.
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影响因子：
3.2
作者：
Lee, S.;Mueller, M.;Spencer, N. D.
通讯作者：
Spencer, N. D.
影响因子：
14
作者：
UYAMA, Y;TADOKORO, H;IKADA, Y
通讯作者：
IKADA, Y
影响因子：
5.5
作者：
Lee, BP;Chao, CY;Messersmith, PB
通讯作者：
Messersmith, PB
影响因子：
5.5
作者：
Lee, S;Iten, R;Spencer, ND
通讯作者：
Spencer, ND
影响因子：
56.9
作者：
Lee, Haeshin;Dellatore, Shara M.;Messersmith, Phillip B.
通讯作者：
Messersmith, Phillip B.