Theory of mind impairment in schizophrenia: Meta-analysis
Theory of mind impairment in schizophrenia: Meta-analysis
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DOI：
10.1016/j.schres.2008.12.020
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发表时间：
2009-04-01
影响因子：
4.5
通讯作者：
Pantelis, Christos
中科院分区：
文献类型：
--
作者：
Bora, Emre;Yucel, Murat;Pantelis, Christos
现在有大量的证据表明精神分裂症患者的心理理论（ToM）受损。尽管如此，我们对动态（状态）变量和广泛的临床，认知和药物特征如何调节任务执行过程中观察到的ToM缺陷的精确程度知之甚少。使用36项研究进行荟萃分析，这些研究报告了精神分裂症患者和健康对照受试者的心理理论表现的连续数据。这36项研究包括1，181例（67%男性）精神分裂症患者和936例（58.3%男性）健康对照受试者。还对暗示和眼睛任务进行了个体分析。调节变量的影响进行了亚组和荟萃回归分析。整体心理理论表现和个体任务的效应量（Cohen's d）较大（d = 0.90-1.08）。在“缓解”患者中，ToM损害的程度不如非缓解患者明显（d = 1.21），但仍具有显著性（d = 0.80）。此外，个别任务的效应量分布更均匀，特别是在“缓解”患者中。精神分裂症患者中观察到的一般智力缺陷只在疾病的缓解期导致他们的ToM受损。虽然状态变量和任务特异性差异在很大程度上解释了在以前的研究中观察到的心理理论研究结果的异质性，但“缓解”患者心理理论缺陷的持续存在表明精神分裂症中存在与心理障碍相关的特质。我们的综述还表明，未来的研究应考虑智商缺陷对“缓解”患者心理理论表现的潜在调节作用，以及残留症状的潜在影响。(C)2008 Elsevier B. V.保留所有权利。
There is now Substantial evidence for Theory of mind (ToM) impairment in schizophrenia. Despite this, we know little about how dynamic (state) variables and broad clinical, cognitive and medication characteristics moderate the precise magnitude of the observed ToM deficit during task performance. Meta-analyses were conducted using 36 studies that reported continuous data regarding ToM performances of schizophrenia patients and healthy control subjects. These 36 studies included 1,181 (67% male) patients with schizophrenia and 936 (58.3% male) healthy control Subjects. Individual analyses were also conducted for the Hinting and the Eyes tasks. The effects of moderator variables were Studied by both subgroup and meta-regression analyses. The effect sizes (Cohen's d) for overall ToM performance and the individual tasks were large (d = 0.90-1.08). In "remitted" patients, the degree of ToM impairment was less pronounced than non-remitted patients (d = 1.21) but it was still significant (d = 0.80). Moreover, the distribution of effect sizes was more homogeneous for the individual tasks, especially in "remitted" patients. General intellectual deficits observed in schizophrenia patients contributed to their ToM impairment only in the remission phase of the illness. While state variables and task specific differences explain a large degree of the heterogeneity of the ToM findings observed in previous studies, the persistence of ToM deficits in "remitted" patients Suggests there are trait related mentalising impairments in schizophrenia. Our review also suggests that future research should consider the potential moderating influence of IQ deficits on ToM performance in "remitted" patients, as well as the potential effects of residual symptoms. (C) 2008 Elsevier B.V. All rights reserved.