Transforming growth factor β: a matter of life and death
Transforming growth factor β: a matter of life and death
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转化生长因子β：生死攸关
DOI：
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发表时间：
1994
期刊：
影响因子：
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通讯作者：
S. Wahl
中科院分区：
文献类型：
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作者：
N. McCartney;S. Wahl
转化生长因子-β是一种与胚胎发生、发育、免疫和炎症过程有关的分子，具有多种功能，其中许多功能是相反的。这种促进或抑制细胞生长和功能的矛盾行为，虽然在正常生理和动态平衡中很重要，但可能导致或中断病理后遗症，使转化生长因子-β成为一个特别耐人寻味的研究分子。显示转化生长因子-β1表达靶向改变的新的转基因小鼠模型为确定转化生长因子-β的基本功能提供了新的和独特的机会(S)。J.Leukoc。比奥尔。55：401-409；1994。
A wide variety of functions, many of which represent opposing activities, have been attributed to TGF‐β, a molecule implicated in embryogenesis, development, and immune and inflammatory processes. This paradoxical behavior of promoting or inhibiting cell growth and function, while important in normal physiology and homeostasis, can contribute to or interrupt pathologic sequelae, making TGF‐β a particularly intriguing molecule for study. New transgenic mouse models displaying targeted alterations in TGF‐β1 expression offer novel and unique opportunities to determine the essential function(s) of TGF‐β. J. Leukoc. Biol. 55: 401–409; 1994.